I'm a little late to the party this week, but FWIW here are my thoughts on week 12.
Overall, it may be a bit tough to put together a killer lineup with the prices so high. Winning will likely depend on finding great value guys to make room for the studs.
At QB we have the usual suspects: Mahomes, Murray, Allen, and Herbert. All are pricey and stacking them will be a challenge. I, personally am not as high on Mahomes as most, but he does have the highest projected FPs per Numberfire of the week. I just wonder if Tampa will slow him down (I know he can not be stopped). The O/U looks good for Murray, but how much will his shoulder injury affect him? Will Belicheck come up with a way to slow him down? Allen and Herbert are in a great matchup as well with a lot of potential. A lot of points and great for stacking, just be ready to pay to play this matchup; although I do like Beasley at $5400 if John Brown doesn't play. But the highest O/U is LVR-ATL. This is my choice to stack. I usually don't like to go big at QB, so Derek Carr and Matt Ryan are my choices. Plus, stacking these are made a lot easier using either Henry Ruggs ($5500) or Nelson Agholar ($5200).
Running Back has a few options as well. Do you pay up for Cook or go mid-range? Also, Henry and Chubb are expected to do well, but can you fit them in if you go big at QB? Personally, I am all in on Cook. Doing that forces me to pay down at the other RB slot. Thus, I am looking at Ballage (assuming Eckler doesn't play) at $5500 and Chase Edmonds ($5800). Also, Samaje Perrine ($4800) is a potential wildcard if Bernard doesn't play. As for Henry and Chubb neither have great matchups, but I feel they have shown potential to do well despite the matchups. FWIW, I LOVE Kareem Hunt this week. I know Chubb will have his solid game, but Hunt's potential and price ($6600) makes him an attractive option for me.
I am not going to talk too much at receiver. These slots will depend largely on who you choose at QB. I would like to mention a few stand alone choices for the flex position. First is Justin Jefferson. If Theilen can not go against CAR, he becomes Cousins main threat at WR and he as already shown big game potential. Another option is Michael Pittman. TEN-IND should be a high scoring game (the challenge is figuring out who gets the TDs). Pittman has been coming along over the last few weeks and at $5700, he could provide some salary relief. One I like is Curtis Samuel ($5900). He is a bit of a boom or bust play, but he is getting more involved in the red zone. Finally, there is Jerry Jeudy. While he hasn't had the big games you would like to see, he does provide a decent floor at a reasonable price ($5700).
Tight end for me will come down to whether or not I go big (Mahomes/Kelce) or not (Carr/Waller) so I will likely be going with the high end TEs. Lower priced options I like this week are Engram ($5600) and Hooper ($5100). Another good choice - if you are willing to gamble - would be either Jack Doyle ($5100) or Trey Burton ($5400); I am fairly confident one will score a TD this week, I just don't know which. Similarly, either Irv Smith ($5200) or Kyle Rudolph ($4600) may be worth a dart throw.
Last on the list is defense. There are a few good matchups I like this week ( MIA, NO, CLE), but I will likely be looking to save at this position. My first choice would be the NYG. A decent defense going against a backup QB, I am in. But if I can not quite fit the Giants in, I usually end up with JAX. JAX defense is not horrible and I don't think CLE passing game is that great so I am taking a chance on them.
After all that, he is how my lineup currently looks:
Carr / Cook / Hunt / Julio / Beasley / Agholar / Waller / Ballage / JAX