I get this question for about ten months a year - both for football and baseball, and I have two standard answers.Note - If YOU firmly believe that there is one single player (or perhaps two) that are heads and shoulders above the rest of the field (from time to time we all do) and that having that particular player is such an advantage (usually it doesn't turn out that way and even when it does it is hard to predict which years that is the case) then that is the spot that YOU want and will feel most comfortable with.BUT - here are the two answers1) The spot in the middle of the draft you feel most comfortable with - for several reasons - you will get a better pick in the second round (and maybe fourth if that is not past the premier talent dropoff); you are better protected against any runs that may ensue (all drafts/leagues have a life of their own and these don't happen in all drafts); and finally, the drafters at either end have two close picks - the first is usually just best player available, but with their second, they have to weigh BPA against ALL the other players that will be drafted in all the picks before their next one - this often causes them to reach, slightly or tremendously, for the player they feel will best help their team (note - they may well be right) - BUT this presents tremendous opportunity for those drafters in the MIDDLE of the draft to take advantage of the talent that inevitably falls while at least a couple of people on Each end are making those reaches.2) THE best spot in any draft is between two morons - advantages are obvious as they constantly take a homer pick or player who would be available in two more rounds, or just forget a player or position.............just saying.