Pulled my winnings out today just in case there's a huge run and they don't have the cash to cover it. Going to leave $50 in for fun.
Just to put your mind at ease, any member of the FSTA, of which the major sites are members, has to have their players' funds in a separate account from their operating funds. For that reason alone, there should never be a problem with the availability of your individual monies.
If you would rather be cautious, that's entirely up to you, but the only way I could see 'losing' our money is if the government intervenes and locks that money while they investigate and/or regulate...which I'm hoping against logic does not happen.