Another day, another positive development in the mRNA vaccine category.
I'm much more enthusiastic about an mRNA vaccine than a standard vaccine. But I'm no expert. Am I missing something?
Standard vaccine: based on a weakened version of the virus. A certain % of the people will get sick from it, that % goes up or down depending on how effectively they balanced weakening the virus itself. If they left it "too strong", they're basically infecting a lot of people with the real deal. "Too weak" and not enough people's bodies learn how to fight it off well enough. Long term issues could be a massive rise in infections and a wave larger than anything we've seen so far.
mRNA: based on the genetic code of the virus's RNA, but made without ever coming in contact with the virus itself. Basically, some scientists decoded the letters of the RNA in the virus, and emailed that to Pfizer and Moderna, and they've been working off of that text. Identified the protein in the points/spikes/"crown" of the virus molecule that latches on to normal cells, and uses the RNA signature of that specific protein to help the body identify and combat it before infection can occur. What are the potential downsides? I can see two... first, that by some weird biology, the protein on the spiked end of the virus is also by coincidence somehow a heretofore-unknown but vital protein that is also present in nature and is essential for human survival, but, hadn't been discovered yet. And we accidentally inoculate ourselves against it. Likelihood? Near zero? Second... maybe it gives a false sense of security? And results in some small waves/spikes/upticks in infection later in 2021? Likelihood... 5%? 10% But manageable?
Anything else I'm missing? Other than the one in a trillion shot that "oh, it turns out that the coronavirus spike protein is actually essential for life on Earth, but has been invisible for the last hundred years, and now we accidentally made ourselves immune to it", I don't see much risk in the mRNA-based vaccines, especially compared to the risks of a standard vaccine. You're not getting the weakened virus. It's never even seen the virus or been in the same room with it. It's just giving your immune system a photograph on a Wanted Poster for the virus and telling it how to kill it.