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Nathan R. Jessep

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Everything posted by Nathan R. Jessep

  1. I'm giving them a shot. Do you have the Video on Demand option? I was just curious what exactly that was. It reads like it gives you links to TV shows and movies (like the Cinema app). I got the one without that for my trial, but might upgrade to that if there are reliable links and no buffering.
  2. Have only had time to skim the thread the last week or so, but did you post how to acquire the comic ones? I was thinking you had, but then went back and couldn't find it.
  3. I don't think we have any clue on herd immunity. Vaccination alone is not high enough yet, but we don't know (nor have we ever known) how many might have natural immunity. Delta cases are falling in some regions and rising in others. I'm not sure if we are following the same pattern (from region to region) as past waves. Would be interesting to see if that's the case.
  4. Here is Pfizer's briefing document to the FDA yesterday if anyone wants to see it: https://www.fda.gov/media/152161/download
  5. You're right. All paranoia I guess. Fortunately none of us in here that live in the south needed an ICU bed (for ANY reason) in the last 3-4 weeks or we might have a different opinion.
  6. Yep, and despite our falling overall numbers here in the US, as someone else mentioned above it's still regional in severity. Some are falling while others are rising. I know that here in our state our numbers are finally falling after a brutal August, but they're just now back down to the end of July level, which already wasn't great, and as we have seen multiple times now, the switch can flip very quickly. Fall is arriving and people will be indoors more, so I am still concerned for the areas (like mine ) with a poor vaccination rate. And not to GB culdeus, but I get a little nervous every time he declares the pandemic over. He's 0 for 3 so far.
  7. Which is precisely what the aforementioned health authorities have not done (or have done way after the fact). Which is where following good sources of news and data comes in clutch, because those health authorities get called out for their missteps. Whereas other sources (looking at you, main stream media) just throw out clickbait bleeding edge headlines to garner views. Unfortunately the latter is what gets shared and discussed most of the time.
  8. https://yourlocalepidemiologist.substack.com/p/no-3rd-shot-for-now-fda-cliff-notes (notes from today's meeting by Your Local Epidemiologist) she summarizes the presentation and then adds Q&A and Discussion points from it: Q&A After presentations, voting members were able to ask the CDC, FDA, Pfizer, UK, and Israel representatives questions. This is where we got a lot of important answers. Here are a few: Why is there so little reporting on cellular immune response instead of just neutralization antibodies? What evidence does Pfizer have? And what does cellular immune response look like for the average person? Pfizer responded by saying it had great data on memory B-cell and T-cell response after immunization. B/T-cell response is working great among the general population. B-/T-cell immunity isn’t good at protecting against infection and spread. We need neutralizing antibodies to do this. Why not make the 3rd dose for the Delta variant specifically? Pfizer said Delta is not escaping immunity like Beta is/was. There is scientific evidence that protection is not just waning for Delta, it’s waning for other variants too. So, this isn’t mainly a Delta problem; it’s more of a timing problem. Why don’t we know the specific antibody titer needed for protection? Israel is studying this right now but, but won’t have results for another month. Pfizer has looked at this and were unable to come up with antibody threshold. They said this is a much more complicated story than neutralizing antibodies. Discussion Then a discussion among only voting members ensued. Frustrations, really centered around data, were aired: Members discussed Pfizer’s surprising answer that they, in fact, had B/T-cell data and didn’t share it in their presentation. If B/T-cells are mounted, then the general population would have protection for a long time. So, this gets even more confusing… Why is Israel’s vaccines not working against severe disease? We desperately need to see Pfizer’s data on B/T-cell protection. Voting members voiced frustration about lack of safety data. Particularly, the risk-benefit ratio for myocarditis. The Pfizer clinical trial of 3rd shots was very small sample (~300 people). So no reassurance was provided for myocarditis. But, unfortunately, this is only really able to be answered post-licensure approval. Vaccine-induced myocarditis is so rare that we need millions of people vaccinated to see the “true” effect. An in-depth benefit-risk analysis could provide insight into whether the benefit of vaccinating younger with a 3rd dose is better than the risk of potential myocarditis from a 3rd dose. This was missing from the presentations today. While Israel started to see increase in severe cases, we haven’t seen that in the United States. But then others questioned…do we want to wait to see if this happens in the United States? A third dose may benefit transmission. But we haven’t seen this data. If we had this data, it would really change the game that we could (or could not) impact R(0). If we want to stop the pandemic, will vaccinating the vaccinated again really make a meaningful impact? To make the biggest impact we need to vaccinate the unvaccinated. Some members stated that this transmission could help with the current pediatric cases surge while we wait for the pediatric vaccine.
  9. There was at least a mini-drop this morning. I saw Topps Chrome show up for one refresh, then it was gone. I'm hoping my first score will be when they release Optic BB or Select FB.
  10. That's the data that launched the debate among medical experts, even about half of Israel's. The prevalence of Delta coincided with the '6 month' timeframe (the waning immunity theory), and the experts are split on what caused the findings in the study. And re: Pfizer vs Moderna, Pfizer was given first, so it will be another few weeks before they can say with certainty if Moderna has truly outperformed, or if it just hadn't hit the waning period yet (if that ends up being the cause in the first place). And this is the entire point of the debate. Do we really want to set a policy based on a guess (which is what Israel basically did)? IDK the answer to that.
  11. Thanks. Were they basing it off of the one big study from Israel (from a couple weeks ago) or other data? or did they say?
  12. I see what you're saying, but I don't think that necessarily applies to medications and vaccines. There are plenty of reasons to not recommend boosters right now. Number one being they might not make *that* much of a difference in effectiveness if we administer them right now, rather than a little later. That's the whole crux of the argument of "is it Delta or is it waning immunity?" Either way the vaccines are still working quite well currently. Additionally, should the need arise later for a formula change that would need to be given to most everyone, there wouldn't be much clinical data on what a fourth dose might do to people.
  13. Which likely means that they are just guessing. Which is exactly what has a lot of experts wondering why the push for boosters with no solid data to back it up yet.
  14. I agree. This coupled with the inability to pivot on a particular point of view (about ANYTHING). People get so dug in on anything and everything. It's sad and frustrating.
  15. quoted from an email newsletter so no link to the "article" but: NIH launches nationwide studies of long Covid The enduring mystery of the persistent effects of Covid-19, better known as long Covid, will be explored in large-scale national studies of research volunteers from diverse populations, the NIH announced yesterday. An award of nearly $470 million to New York University Langone Health will fund new studies of Covid-19 survivors and expand current long-running large cohort studies. The NIH REsearching COVID to Enhance Recovery (RECOVER) Initiative aims to learn why some people have prolonged symptoms or develop new or returning symptoms after they recover from the acute phase of infection. The most common symptoms include pain, headaches, fatigue, “brain fog,” shortness of breath, anxiety, depression, fever, chronic cough, and sleep problems. Studies will include adult, pregnant, and pediatric patients with an emphasis on racial diversity.
  16. yes, and I think that's what they are still trying to determine
  17. I posted this one last week But yeah, he makes a good argument. I've still not seen anything out of Isreal, including the stuff today, that refutes his theory yet.
  18. I saw that note when I signed up, but I answered a couple of questions and it said I was verified. Now, I haven't had the chance to buy yet, so IDK if I might get hit with that too. Did your account say verified prior to this incident?
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