It would probably be more complicated than what is is worth, but I've always thought about having "home field advantage" where the home team gets to dictate the lineup of their home games, like this:
1. Ground and pound: QB, RB, RB, RB, WR, TE, TE, K, D
2. Spread: QB, RB, WR, WR, WR, WR, TE, K, D
3. Standard: QB, RB, RB, WR, WR, WR, TE, K, D
So the home team AND the visitor have to set the same style of lineups, whichever one that the home team chose. You could play to your team's advantages or play to your opponent's disadvantages. Hell of a headache for the commish to m