Appreciate the comments Freelove, Jumper and Adam.
Would you be more inclined to look at TE / QB earlier? If I go RB/WR at 10/11 would it make sense to follow with TE/QB at 30/31and then load up on RB/WR with the remaining picks?
It's going to depend a lot on knowing your league and its tendencies. I participate in a lot of staff mocks and "industry drafts" with other writers and analysts from around the web. In a league like that, I would never dream of taking a quarterback in the first three rounds; the idea of waiting at quarterback has become so ingrained in "expert" culture that spending a first or second round pick at the position essentially amounts to needlessly wasting draft capital.
At the same time, I also have a few "Friends & Family" drafts; there I would think nothing at all of selecting, say, Peyton Manning at the 1/2 turn. I know that Brees and Rodgers will both be gone by the time the draft rolls back around to me, (and, if history is any guide, perhaps one or two second-tier quarterbacks will have joined them). I also know that I'll be able to consistently pick up sliding value through the rest of the draft to make up for a potentially weaker start at the beginning.
My willingness to take a QB or TE early, however, is contingent on the QB or TE in question. As the saying goes, it's all about the studs. If I miss out on Manning/Brees/Rodgers or Graham/Gronkowski/Thomas/Cameron, I'm probably ignoring the position for quite a while unless a Jordan Reed or Nick Foles starts slipping in the middle rounds.
Here's a 10-team mock the staff ran earlier this offseason; I drew the #1 overall pick and started out Charles, Peyton, Nelson, Cameron, and Brees. Part of that was curiosity about how the remainder of the draft would turn out if I grabbed two of the top three quarterbacks, but it illustrates how in a 10-teamer you can get away with a bold gamble like that because the positional depth is a bit less punishing.
For those who can't see the article, (I believe it is behind the paywall), here was my final team:
QB- Peyton Manning, Drew Brees
RB- Jamaal Charles, Pierre Thomas, Frank Gore, Bernard Pierce, Fred Jackson
WR- Jordy Nelson, Julian Edelman, Eric Decker, Brandin Cooks, Marvin Jones, Kelvin Benjamin, Kenny Britt, Josh Gordon
TE- Jordan Cameron
Obviously I'd be throwing stuff at the wall hoping it sticks at WR in the early going, but I think those situations will become much more clear by midseason (and there's usually quality help on the wire in a 10-teamer). I was also partially emboldened by the fact that this was early July and I figured I could grab some rookies at a discount before the buzz started building- neither Cooks nor Benjamin would be available quite so cheaply today. On the other hand, this was against FBG staff members, who as a group are pretty on the ball; in a less competitive league there would be even more value later in the draft to fill those WR2/3 and RB2/3 holes.
Toby Gerhart was selected before Drew Brees in that mock, which I think was just people not being familiar with the format. I guarantee you if I was so inclined I could trade Drew Brees for Toby Gerhart straight up a week or two into the season in a 10-teamer.