If you start with AP or CJ, you are already in a great position. There are three ways you can go depending on your QB scoring (3pt TD's or 6) RB, WR WR if you are ppr, you may want a solid core of Wr's in there. Lastly is to go RB, RB, best avail...
I like to think in the later you may be able to land a guy like Greene, Benson or perhaps matthews (depending on hype) with the second pick and take a Tier 2 WR (boldin/S Smith). the beauty of this draft style is you are drafting out of sync with all the clowns who went QB, or WR in the first few rounds... while they are scrambling for RB's, you are cherry-picking elite TE's and perhaps a tier 2 Qb like Rivers in the 4th...
second is to go RB, WR, WR and hope to nabb two solid WR's like megatron, marshall, Jennings and Smith, Boldin or ocho next. remember WR's take a huge drop off after the tier 3's are gone (Bowe, MSW, Floyd, etc) so having solid Wr's is key. RB's Te and QB are deep this yr so you can wait...
Third is going for a top guy in all three slots. AP, Marshall, Romo... while this looks nice on paper it doesnt allow you to create a strong area in your bench. you will be after WR's and RB's at the same time as everyone else and what i find is you tend to take a top 5 TE with the 4th round pick over the likes of the other RB's there... this style of draft does not endure injury well..