Any Science Guys Care to Translate Some Science for Me? (1 Viewer)

[chet]

•Proof of concept study to determine if simultaneous HPV E6,E7 mRNA and PD-L1 is possible on cervical cytology samples. 

•Here we show dual E6,E7 and PD-L1 expression on the same sample. This information is currently not available in a single test by any other method. 

•Based on this small sample set, PD-L1 expression decreases in high grade lesions. Additional samples should be tested to confirm this finding. 

Thanks.

Paging @Mr. Pickles !

 

[ChiefD]

Ball cancer. 

 

[Ilov80s]

Don't know all of it but E6 and E7 are proteins that when overly expressed can significantly increase the risk of cervical cancer. PD-L1 are another group of proteins that work in the immune system to determine what to target and what to leave alone. Sometimes when people have cancer the PD-L1  in the cancerous cells tells the immune system not to attack the cancerous cells. 

 

[The General]

Don't know all of it but E6 and E7 are proteins that when overly expressed can significantly increase the risk of cervical cancer. PD-L1 are another group of proteins that work in the immune system to determine what to target and what to leave alone. Sometimes when people have cancer the PD-L1  in the cancerous cells tells the immune system not to attack the cancerous cells. 

Whoa

 

[Parrothead]

It's a boy!

 

[The General]

All I know is you don’t want any part of “high grade lesions”.

 

[chet]

Don't know all of it but E6 and E7 are proteins that when overly expressed can significantly increase the risk of cervical cancer. PD-L1 are another group of proteins that work in the immune system to determine what to target and what to leave alone. Sometimes when people have cancer the PD-L1  in the cancerous cells tells the immune system not to attack the cancerous cells. 

Overly expressed?  Does that mean they occur in cells at a higher rate than normal?

 

[kevzilla]

HPV is human papilloma virus, a sexually transmitted organism that can cause cancer in men and women. mRNA is mitchodrial ribonucleic acid. That's all I got.

 

[Dezbelief]

Any Science Guys Care to Translate Some Science for Me?

Get you HPV shots.

 

[Ilov80s]

Overly expressed?  Does that mean they occur in cells at a higher rate than normal?

Yeah, basically its making too many copies of the protein. I think the e-6 and e-7 are tied to regulation of the cell's life so it plays a role in the cancer cells becoming immortal. 

 

[TheIronSheik]

Bulkhead?

 

[chet]

Bulkhead?

No. I got to my seat this morning and found it unoccupied!  I am now flying from SFO-ORD.

 

[Tom Skerritt]

Nevermind. I’m stupid. 

 

[Tom Skerritt]

HPV E6/E7 are genes within HPV that inactivate tumor suppressor proteins. Thus promoting tumor growth. 

PD-L1 is a ligand protein that also seems to allow tumor growth when present  

Perhaps your OP suggests using HPV E6/E7 to inactivate PD-L1... so that the body could then mount the proper immune response in its absence. And thus, a reduction in tumor size/growth. 

 

[Terminalxylem]

HPV E6/E7 are genes within HPV that inactivate tumor suppressor proteins. Thus promoting tumor growth. 

PD-L1 is a ligand protein that also seems to allow tumor growth when present  

Perhaps your OP suggests using HPV E6/E7 to inactivate PD-L1... so that the body could then mount the proper immune response in its absence. And thus, a reduction in tumor size/growth. 

I think this is partially correct. E6 and E7 are HPV proteins which promote cervical intrepithelial neoplasia converting to invasive cancer.  PD-L1 is a target for cancer immunotherapy, as it is a “checkpoint” between some cancer cells and our immune system.

A single assay which measures the risk for cancer progression (E6/E7) coupled with a marker for cancer therapy (PD-L1 inhibitors) would be of value for women with CIN, especially if it could be obtained from something like a Pap smear. 

ETA It doesn’t appear PD-L1 inhibitors are FDA approved for cervical cancer but are for urothelial carcinoma, of which some subtypes may be promoted by HPV infection.