I'm probably going to start Pryor over Wilson vs SD defense. I think it's just that week to week it's very hard to predict game scripts for the Seahawks, how much Wilson will actually throw, whether he will get any passing TDs vs whether Lynch will run them all in. Even when he had his 4 TD game vs the Jags, 2 of those could easily have turned out to be rushing TDs. The other thing is that, apart from the end of last week's game, like Kaepernick, he's just not running much this year. So while Wilson is a terrific real life QB, for fantasy he's on a run first team, that doesn't need him to throw necessarily to win - he's a high variance, high upside guy, but he also has a very low floor which can kill you in a matchup. And that makes him tough to start over a number of QBs who are more likely to at least put up serviceable numbers every week.