Too many variables to just flatout say "RB/WR/RB/QB" or "RB/RB/WR/WR" or whatever...
Everything depends on where you are picking from and who is available. I can say though, that I'm a big believer in building an overall team in the first 4-5 rounds and my personal draft strategy will be to come out of the early rounds with a RB1, RB2, WR1 and Antonio Gates as my TE in tight-end required leagues.
I may sacrafice the RB2 for a WR2 depending on who is available and who I think I can get in the middle rounds, but essentially, if I can pull off a stud running back, a stud wide receiver, and Gates as the 3 cornerstones to my team next year after the first 3 rounds, then I'm happy.