Here's a first draft, as it were. I'm sure I'm forgetting something, so I may come back and edit this list.
Top 10
Michael Chabon:
The Amazing Adventures of Kavalier & Clay
Jonathan Franzen:
The Corrections
John Wray:
Canaan's Tongue
Roberto Bolaño:
2666
Kazuo Ishiguro:
Never Let Me Go
David Mitchell:
Cloud Atlas
Cormac McCarthy:
No Country for Old Men
Roberto Bolaño:
The Savage Detectives
Michael Chabon:
The Yiddish Policemen's Union
Junot Diaz:
The Brief Wondrous Life of Oscar Wao
Honorable Mention
Ian McEwan:
Atonement
Richard Russo:
Empire Falls
Thomas Pynchon:
Against the Day
Susanna Clarke: Jonathan Strange & Mr Norrell
Cormac McCarthy:
The Road
Aravind Adiga:
The White Tiger
Khaled Hosseini:
The Kite Runner
Books that might appear on some peoples' lists, but will absolutely not appear on mine include:
Yann Martel:
Life of Pi
David Wroblewski:
The Story of Edgar Sawtelle
anything by Dan Brown
Probably should start a non-fiction list as well (Consider the Lobster, Heartbreaking Work, John Adams ...)