The smart thing to do is go with MJD or RR and go with the best wr avail (assuming a worthy wr is still on the board) in rd 2. The reason you do this is because the dropoff from MJD/RR to whatever rb you would take in rd 2 is likely to be greater than the dropoff from Andre to whatever receiver you would take in rd 2.
See, this is the line of thinking I am not sure I agree with. I think the drop off from the top tier WRs is equal to or greater the drop off from the top teir RBs. Also, like others on this thread
I have questions about MJDs durability after his heavy workload last year. Plus I hate his offense. Those concerns aren't there for Rice, but he could have his TDs vultured again and I expect his pass catches to come down somewhat. I think 'dre is almost a sure thing in that Houston offense, which I think will be even better this year. To me outside of AP & Rodgers, AJ is the player with the least amout of question marks... if he is healthy he will get his.