Broncos seem to have some key WRs injured so Titans secondary success could very well continue
The only one missing is Royal (yeah I know Thomas is hurt too but he's pretty much been hurt since he came into the league). I think Decker playing more than Royal is a good thing for the Broncos. Plus, they'll have Moreno back and while I don't think he's a lead back I do think he's a good third-down RB. So Orton has a good complement of weapons to work with this week. Whether he'll get it done is the question but that's always the question with Orton.
If the Broncos can get a decent running game going Orton will likely play much better. I don't think it's a coincidence that they couldn't run the ball in Week 1 and lost with Orton playing poorly but they won in Week 2 with Orton playing well and their running game looking better. Orton isn't the type of QB who can win games with his arm. He needs help. If the Titans take away the running game I think they'll force Orton into mistakes and win. If Denver can get it going running the ball, I wouldn't be surprised to see them win the game. Lloyd and Decker are a better WR duo than the Titans have faced this season (Jacksonville has poor WR talent and the Ravens had Boldin and a gimpy Evans last week).