In league #1, I own both Brees & Cooks, and in league #2, I own only Cooks.
In league #1, I am a significant underdog, plus I had Gates do nothing for me on TNF already. My only QB alternative is Hasselbeck. Unless there is either clear word or rampant rumor that Brees will be inactive, I am keeping Brees in my lineup. I also have no alternative bu tot start Cooks, so Brees' status is irrelevant to my lineup decision WRT him.
In league #2, the matchup is a toss-up. If Brees is active, I'll keep Cooks in my lineup. If Brees is inactive, I'll start Diggs instead.