In a standard scoring league (1 point per 20 yds - 4 points per TD), drafting Manning before a bonafide RB2 or WR1 is fantasy football suicide. I have yet to see a GM win the league by drafting Manning in the first round or early in the second. If it's a league where they award bonus points for 300 yards and 6 points per TD, then drafting Manning in the late 1st/early 2nd makes sense. I'll grab a RB1/WR1/RB2 or RB1/WR1/WR2 type combo to then strike at getting a Bulger, Brees, Brady in the 4th round. I may even let things slip and grab Kitna somewhere in the 5th/6th. Let the Manning owner have ulcers on deciding who would be his best RB combo between the likes of Tatum Bell, Lamont Jordan, Jerious Norwood while praying that Lendale White finally breaks out cause he picked him too early.