Unless your league rewards quite handsomely for holding an offense to a low score, I'm going to make an argument against the case for Carolina:
1) Buffalo gives up very few sacks. They did an excellent job last year in that department and gave up zero in Week 1. LT Cordy Glenn didn't even give up a pressure. Wood is also an excellent pass blocker and Urbik and Pears can hold their own. Furthermore, Buffalo's passing offense focuses mainly on quick developing plays so getting to the QB is very difficult, especially when it's a guy like Manuel. So the odds of getting a bunch of points via sack is really low.
2) INTs will be really hard to generate against Manuel right now. The Bills are really babying him. So everything is very quick and short. You won't see him make too many tough throws at this point. Manuel is still working on timing with his WRs after missing half the preseason and being a rookie though, so there may be an opportunity or two there. But through 2 preseason games and one regular season game, he's been very efficient and not prone to turning it over.
I think there's a good chance that the Panthers have a nice day in NFL terms stopping the run and holding the Buffalo offense to a low score, but I'm not sure it's going to translate into a high fantasy score.