This year, in particular, the back end of the draft (in a serpentine draft) can give you a solid WR-RB combo or even a solid RB-RB in the first two rounds. In mock drafts, I've been able to consistently get one of the big four receivers (Moss, Fitz, Calvin, Andre) in the first, and I've been able to pair them with backs of the caliber of Brandon Jacobs, Frank Gore, or DeAngelo Williams if I go the WR-RB route. Or I've been able to grab one of those backs in the second round while still grabbing someone like Steve Slaton in the first. That gives you, in my opinion, a better 1-2 punch than the top of the draft will offer this year.From a strategy perspective, I prefer picking close to either end of the draft (1,2, 3 or 10, 11, 12) rather than picking in the midlle because it's easier to anticipate how the other owers will pick, and you can plan accordingly. For instance, if I'm picking from the 10 spot and I'm targetting picking Carson Palmer as my QB in either the 7th or 8th round, if I see that the owners picking from the 11 and 12 spots already have QBs on their roster I can anticpate that it's unlikely that they will take another QB this early in the draft so I can pass on taking Palmer in the 7th and I'll feel confident that Palmer will still be there in the 8th when I pick next. I can then invest that 7th round pick in a talent that either that 11th or 12th owner might take before the draft gets back to me in the 8th. That kind of strategizing is more difficult from the middle of the draft because there are more owners to account for, and there are more draft picks between your turns.