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In a 2QB league you want as early a pick as possible to lock up the studliest QB you can. Are you asking because you get to choose your draft slot? I'd want #1, then #2, and on down the line in that order.
For me, if there is someone you must have then pick as low as you can to still get that guy. I prefer the ends so I would likely want a top 3 or bottom 3 pick. For a redraft I don't think draft position matters in as much as it is for a preference.
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