Why not?PhD in genetics here. I wouldn't.
Yeah, please explain. Just too general of a report or what?PhD in genetics here. I wouldn't.
I'd probably rather know than not know. Who knows, maybe you learn something about health risks you didn't consider to be significant previously. Or you cross your genetics with your wife's and figure out whether there are any significant risks to watch out for with your kids?People learn stuff they don't want to.
This is essentially the story of my brother. Searched for his biological parents for years without success. A woman contacted him looking for her twin. They were adopted from the same agency at about the same time. He submitted DNA to compare to her. No match, but that put him in the database. Meanwhile, my first cousin and her husband decided to do the testing just for fun and curiosity. They happened to choose the same database, and boom, after never knowing his biological past for 57 years, he stumbled upon a first cousin. His daughter made the initial contact with my cousin, and the puzzle pieces started falling in place. My oldest sister then submitted her DNA to the same company, and sure enough it matched at the sibling level.I am adopted so i have thought of doing this as well. I truly have no idea about my background.
Well that is pretty blunt. 23and####off.comI doubt much useful information would come of it. Not sure if this has been resolved but:
http://www.forbes.com/sites/danmunro/2013/12/02/class-action-law-suit-filed-against-23andme/#6c1f123559c6
I am selling personalized PGx testing for a local lab on the side.With the price of genetic testing plummeting and the pimping of "personalized medicine" I think this will become common in a few years. For specific disease treatment it can be life changing, as certain drugs are better for particular gene mutations than others.
I'm sure it is a fine service but it works off of very limited information (insert sciency science explanation here). Then let's say that you find you have a possible predisposition to heart disease, I am guessing you already know that information based on family history btw, is that the information that will finally make you change your lifestyle? You may say yes but I am not certain that you would and you are just as likely to suffer from stress related to the knowledge that 1) could cause just as much harm and 2) ultimately is only suggestive and not of predictive value it is simply not diagnostic quality information. And flip that on its head, what if your results come out "clean" (again based upon very limited, not diagnostic, information) how do you think you would respond to that Otis? Healthy lifestyle changes or more of what we see regularly in the Otis v Woz thread?Why not?
Is it that you'd rather not know some of the stuff you'd likely learn? (i.e., hereditary and health issues, etc.) Or just that it's crap and doesn't work?
So save your money and you die when you die?I'm sure it is a fine service but it works off of very limited information (insert sciency science explanation here). Then let's say that you find you have a possible predisposition to heart disease, I am guessing you already know that information based on family history btw, is that the information that will finally make you change your lifestyle? You may say yes but I am not certain that you would and you are just as likely to suffer from stress related to the knowledge that ultimately is only suggestive and not predictive, nor is it diagnostic. And flip that on its head, what if your results come out "clean" (again based upon very limited, not diagnostic, information) how do you think you would respond to that Otis? Healthy lifestyle changes or more of what we see regularly in the Otis v Woz thread?
I don't see that it will provide you any positive benefit for you.
If you seriously want to get undergo these types of tests I suggest you put up about $20,000 and contact Human Longevity Inc in San Diego. It's Craig Venter's new joint (the guy who loves to tell everyone who will listen, and those who don't want to, that he was responsible for sequencing the human genome. It was much more complicated than that but he isn't entirely incorrect) and the focus is aging and complete biome sequencing. It is still nascent but it will provide a comprehensive analysis that is far, far more likely to provide you with actionable information.
Yes/no. I am very interested in what they are trying to accomplish at HLI, it is still very early for them but whole biome testing, which includes your whole genome sequencing, not just the extremely limited number of markers they test at 23&me, and the entire genome of all the organisms that live inside and on you, which is a mind blowing number. It is far, far more likely to provide you actionable information.So save your money and you die when you die?
Now you're just showing off.I have two PhDs in genetics and I say go for it.
Thanks Doc. Unrelated question, do you expect us to be living to 100+ years on average the next generation, the millennials? Things seem to be moving fast in this field.Yes/no. I am very interested in what they are trying to accomplish at HLI, it is still very early for them but whole biome testing, which includes your whole genome sequencing, not just the extremely limited number of markers they test at 23&me, and the entire genome of all the organisms that live inside and on you, which is a mind blowing number. It is far, far more likely to provide you actionable information.
Now if you are a woman who has a family history of breast cancer then I absolutely recommend having your BRCA markers tested, but go to a doctor and have the tests done in an environment that will provide you the support you need to deal with potentially devastating news should it be necessary.
There are very, very few truly diagnostic genetic tests that would be relevant to the overwhelming majority of the population. If you suspect you are at risk from one of these rare disorders, or even the less rare ones, and you would suspect that because of a family history, that can be diagnosed via genetic testing, then you should be dealing with them in a professional health care environment not with some mail order saliva swab test.
Knowing Otis, I'm assuming that I should be able to find someone to provide this service for about $50.Got curious after looking at the website, tempted to order a couple of kits for me and Mrs. O. It's $199 a pop, so ain't cheap, but it seems legit.
Anyone ever do one of these? Interesting? Worthwhile?
TIA
Agree with all of this. With regards to HLI, I wouldn't pay 20k for their services, the price will come down a ton. In addition to the genome sequencing, they also want to look at how an individuals genome changes over time. They want to build a model to predict which changes in the genome lead to certain diseases by generating a huge database and then using computer learning to find these correlations. It is a long way off and may not work at all but its a cool concept. The founders have done TEDx talks and similar talks to get the idea out there.Yes/no. I am very interested in what they are trying to accomplish at HLI, it is still very early for them but whole biome testing, which includes your whole genome sequencing, not just the extremely limited number of markers they test at 23&me, and the entire genome of all the organisms that live inside and on you, which is a mind blowing number. It is far, far more likely to provide you actionable information.
Now if you are a woman who has a family history of breast cancer then I absolutely recommend having your BRCA markers tested, but go to a doctor and have the tests done in an environment that will provide you the support you need to deal with potentially devastating news should it be necessary.
There are very, very few truly diagnostic genetic tests that would be relevant to the overwhelming majority of the population. If you suspect you are at risk from one of these rare disorders, or even the less rare ones, and you would suspect that because of a family history, that can be diagnosed via genetic testing, then you should be dealing with them in a professional health care environment not with some mail order saliva swab test.
Good info. Appreciate it. I just sent mine in but I'm only doing it for the family tree thing & what percentage I'm Irish & what percentage idiot.I'm sure it is a fine service but it works off of very limited information (insert sciency science explanation here). Then let's say that you find you have a possible predisposition to heart disease, I am guessing you already know that information based on family history btw, is that the information that will finally make you change your lifestyle? You may say yes but I am not certain that you would and you are just as likely to suffer from stress related to the knowledge that 1) could cause just as much harm and 2) ultimately is only suggestive and not of predictive value it is simply not diagnostic quality information. And flip that on its head, what if your results come out "clean" (again based upon very limited, not diagnostic, information) how do you think you would respond to that Otis? Healthy lifestyle changes or more of what we see regularly in the Otis v Woz thread?
I don't see that it will provide any positive benefit for you.
If you seriously want to get undergo these types of tests I suggest you put up about $20,000 and contact Human Longevity Inc in San Diego. It's Craig Venter's new joint (the guy who loves to tell everyone who will listen, and those who don't want to, that he was responsible for sequencing the human genome. It was much more complicated than that but he isn't entirely incorrect). The focus is aging and complete biome sequencing. It is still nascent but it will provide a comprehensive analysis that is far, far more likely to provide you with actionable information.