Yes/no?
Do you mean our specific Species, or some lineage of "beings" that fall directly from us, or some combination of both be the determiner genetic or "if we are like what humans are, today"
In the short term, it comes down to having one or multiple cataclysmic events. Nuclear Holocaust on a grand scale, a virus or series of virus / bacterium that we can't control. Rising water that tips the scale of world power and balance, creating widespread ongoing war, possibly isolated some communities while potential degredation of technology - who the hell knows. As noted, maybe we end up on other planets.
In ALL of these scenarios, I don't see every single human going extinct. Some will survive - due to genetic mutation, luck, the latter than then results over time in the former. Not sure how much of that mutation will be immediate, or within one or two generations, or get things started for a drastic evolutionary change to occur later - but at what point are we "not human" at least if there is some huge environmental stressor before 2200. With 80 years to go, my short answer would be we will be around, but quite likely on our way on a major divergence genetically from what we have been over the past what, 20,000+ years, if not further back?