It's not non-PPR that killed interest when I viewed. I lost interest once I saw start 2 QB. I don't, and wouldn't play in such a league, and as such, don't have any constructive thoughts. Simply haven't given it any consideration, and don't feel qualified.
For general standard leagues (and PPR as well), I've come around to the idea of WR/WR from virtually every draft slot. Earlier in the year, I was on board with grabbing a big 4 type RB or a Luck if I drafted early, but the very reliable composition of the drafts this year just seems to mandate going about it differently.
Rounds 3 through 8 or so, every draft, seem to have tons of values at RB, while at literally every other position, I am every bit as happy with the late round options as I am with the mid-rounders. So it only makes sense to use those rounds to stuff my RB corps. And if I'm going to do that, what does that mean for the early rounds?
I think the dropoff from the top...what is it, 8 or so?...WR's is clear and substantial, and they are gone, gone, gone by 3.1 literally every draft I do, real or mock.
The only real other consideration for me is grabbing a Rodgers or Luck in the first (or second if one falls), but I'm a lot more confident that I see predictable breakout candidates among the late-round QB ranks than I do for WR's.
So literally, even if I firmly believe Peterson, Lacy, or Bell or someone is going to earn those top value slots, my team is stronger if I bypass them and "reach" for Brown, Dez, or whoever.
Obviously, 100% of that goes out the window in a 2QB league, though.
Equally obvious, if either your top WR tier extends a little deeper, or your 2nd tier is a little closer to tier 1 than mine, it'd certainly be worth passing on WR if you were picking at the top of the first.