6 or 7 is usually best IMO..
you're beyond the hyped players at this point and still able to get a stud RB in the first round..depending on your scoring system ( PPR is a plus here), you can nab the #1 wr on the board at 6-7, as this is usually the spot where the top 5 RB's have been taken and maybe a QB...you're left with D. McFadden, McCoy, or,say, Andre Johnson...
it seems to me that the first half of the first round is RB territory, the 2nd half is mostly WR's and QBs..so you're
not going to get the top 5 RBs, but you'll get one on the fringe of that, or the best WR in the game..I'd almost rather have AJ than Foster ,because I know AJ will bring it week in and week out..not 100% sold on Foster just yet ( yes, I own him and I'm worried he won't repeat his 2010 performance).
late third round/early fourth is where TE's start flying off the board (if you're league uses PPR for WR/TE). so you're in the thick of things where that is concerned..
being in the middle of a round also means your in the middle of most player 'runs', you know, when guys start grabbing a certain position, one after the other for 5-6 picks in a row..if you're picking 12th/13th, and the run on defenses starts at #1, you're on the outside looking in..
picking first gives you the #1 fantasy player and the 24th/25th.
picking sixth gives you the #6 fantasy player, 19th/30th.
I'd prefer the 6th overall pick for that reason..I don't have to wait 22 picks before it comes back to me..I'd rather work with 6,19,30 instead of 1,24,25 because if the #1 overall pick busts or is injured,i'm screwed..I think you put more weight behind a guy at the #1 overall pick than you would at #6..if I get McCoy at #6, and he gets hurt I could live with it, but if Foster got hurt at the #1 spot, I'd be in trouble..at best, my #2 RB would have been the 24th pick in the draft - i.e., probably not even a top 20 RB..that drop is significant..