I could be way off on this one, but this feels like a huge revenge game coming off that Thursday Night game a month or so back. I think the Rams are the best team in the NFL, they are 2 fluky plays from being 8-0 right now.
I think SF just kinda has an ok game offensively. Not good, or bad. CMC gets his, Kittle should be still ramping up, and Mac could be ok, but I don't expect anywhere near what he did last time.
For the Rams, this 49ers D has lost a lot of talent since then, particularly then DPOY front runner Fred Warner. I think the Rams do whatever they please in this one. Stafford, Kyren, Puka, Adams, all have room to have good games, even by their lofty standards.
Rams-38
49ers-10