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Quarterback
Peyton Manning - Denver Broncos
Manning will have a tough match-up in Sunday nights game vs the Pittsburgh Steelers. Coming off injury i think he will have some rust and facing a very good Steelers defense i would sit Manning just to be safe.
Andy Dalton - Cincinnati Bengals
Dalton will have to face division rival Baltimore Ravens week 1 on Monday night at Baltimore and that doesn't bode well for the second year QB. I would sit Dalton until further notice just encase he endorse a Sophomore slump.
Brandon Weedon - Cleveland Browns
Weedon will have to face the fearse pass rush of the Philadelphia Eagles, and may not have the luxury of having rookie Running Back Trent Richardson in a full workload. The Eagles sacked Weedon 4 times during week 3 of the preseason.
Running Back
Adrian Peterson - Minnesota Vikings
Peterson will be limited for the first few weeks of the season, and with that being said i would hold him out of your lineup for the first 3 weeks of the season to be on the safe side.
Maurice Jones-Drew - Jacksonville Jaguars
After a 38 day hold out MJD will have a limited role in week 1 vs the Minnesota Vikings, I wouldn't start Rashard Jennings either just encase MJD gets vulture time inside the 10.
Donald Brown - Indianapolis Colts
Brown has been far from impressive during the preseason, and hasn't been guaranteed to work the goal line and shortage downs. I would avoid Brown in a tough match-up with a very good Bears run defense.
Wide Receiver
Greg Little - Cleveland Browns
Little will be facing a very solid Eagles secondary, and like i mentioned before the Eagles pass rush ate up the Cleveland offensive line without starting defensive ends Trent Cole and Jason Babin, I wouldn't expect many good numbers for any Brown this week.
Denarius Moore - Oakland Raiders
Moore has been sidelined with a hamstring injury, and still has not been cleared to practice. I would sit Moore week 1 with the likelihood of Rod Streater getting the start.
Steve Smith - Carolina Panthers
Smith has battled a foot infection during the last few weeks, and has just returned to practice on 9-2. I would sit Smith if you have a solid replacement vs a good secondary in Tampa Bay.
Tight End
Jason Witten - Dallas Cowboys
Witten hasn't been ruled out for week 1, but will be a game time decision for at least the first few weeks of the season. I would sit Witten until further notice.
Jermichael Finley - Green Bay Packers
Finley will face a very tough 49ers defense week 1, and the 49ers were a respectable 7th vs Tight Ends last season. With Rodgers spreading the ball around i don't see a lot of targets going Finley's way for this weeks match-up.
Fred Davis - Washington Redskins
Davis will be paired up with rookie Quarterback Robert Griffin in week 1 vs the New Orleans Saints, and i don't think the two have quite jelled yet during the off-season.
Quarterback
Peyton Manning - Denver Broncos
Manning will have a tough match-up in Sunday nights game vs the Pittsburgh Steelers. Coming off injury i think he will have some rust and facing a very good Steelers defense i would sit Manning just to be safe.
Andy Dalton - Cincinnati Bengals
Dalton will have to face division rival Baltimore Ravens week 1 on Monday night at Baltimore and that doesn't bode well for the second year QB. I would sit Dalton until further notice just encase he endorse a Sophomore slump.
Brandon Weedon - Cleveland Browns
Weedon will have to face the fearse pass rush of the Philadelphia Eagles, and may not have the luxury of having rookie Running Back Trent Richardson in a full workload. The Eagles sacked Weedon 4 times during week 3 of the preseason.
Running Back
Adrian Peterson - Minnesota Vikings
Peterson will be limited for the first few weeks of the season, and with that being said i would hold him out of your lineup for the first 3 weeks of the season to be on the safe side.
Maurice Jones-Drew - Jacksonville Jaguars
After a 38 day hold out MJD will have a limited role in week 1 vs the Minnesota Vikings, I wouldn't start Rashard Jennings either just encase MJD gets vulture time inside the 10.
Donald Brown - Indianapolis Colts
Brown has been far from impressive during the preseason, and hasn't been guaranteed to work the goal line and shortage downs. I would avoid Brown in a tough match-up with a very good Bears run defense.
Wide Receiver
Greg Little - Cleveland Browns
Little will be facing a very solid Eagles secondary, and like i mentioned before the Eagles pass rush ate up the Cleveland offensive line without starting defensive ends Trent Cole and Jason Babin, I wouldn't expect many good numbers for any Brown this week.
Denarius Moore - Oakland Raiders
Moore has been sidelined with a hamstring injury, and still has not been cleared to practice. I would sit Moore week 1 with the likelihood of Rod Streater getting the start.
Steve Smith - Carolina Panthers
Smith has battled a foot infection during the last few weeks, and has just returned to practice on 9-2. I would sit Smith if you have a solid replacement vs a good secondary in Tampa Bay.
Tight End
Jason Witten - Dallas Cowboys
Witten hasn't been ruled out for week 1, but will be a game time decision for at least the first few weeks of the season. I would sit Witten until further notice.
Jermichael Finley - Green Bay Packers
Finley will face a very tough 49ers defense week 1, and the 49ers were a respectable 7th vs Tight Ends last season. With Rodgers spreading the ball around i don't see a lot of targets going Finley's way for this weeks match-up.
Fred Davis - Washington Redskins
Davis will be paired up with rookie Quarterback Robert Griffin in week 1 vs the New Orleans Saints, and i don't think the two have quite jelled yet during the off-season.