It's complicated, for Jackson in particular.
Most assume he's not playing any significant number of games for SD this year. So let's move on from there.
Next is what YOU believe is the percentage chance of him being traded this year.
Then, you have to figure out if he misses 3 or 6 games. Either way, that's a value knock-off as well.
Then you have to wonder (or analyze

) how effective he would be wherever he goes.
But for me, even after all of that, he's worth SOMETHING fairly significant. Let's say I guess the odds of him being traded are 50%, that he will be traded before Sept 4th if at all (meaning a 3 game suspension rather than 6), and that he will absolutely be featured by any team willing to make the investment in him (would be crazy not to frankly). That "featuring" to me means that he's going to have success, because I believe he is very talented.
So what is a 50% shot at a top 10 receiver for 13 games worth? There again, more factors to consider. What's your league like, is it dominated by studs? Are you very likely to make the playoffs (do you have a strong history in your league) What's the playoff format (if any)?
So the answer is, "It depends. On a BUNCH of things.". I personally might be more inclined than most to pull the trigger in the mid-rounds given a fairly generic redraft scenario.