I'm not sure it matters. It might even help. I know that wasn't the case last year, when everyone was healthy, but Tate is done now. He was splitting time with CJ Board. Shepard should breeze right past him to the #2 WR spot. Target wise, I'm expecting it to go Engram>Slayton>Shepard, with Slayton getting 3-4 deep shots.
Slayton is the same high end WR3 he's been all year, in what is a pretty good matchup. I think there is a 3-40 absolute floor, and a ton of upside, like a 7-125-2 in on the table. The Eagles play to their opponents, and have an awful secondary, other than Slay, who isn't what he once was.
I do like that Darius Slayton v Darius Slay is almost certain to confuse the announce team at some point.