I'm playing Karlos, Miller, and Hightower over CMike...
Hightower is the only one of those 4 who is most likely to get 20 carries. Karlos is second. Lamar Miller is most likely to break an 80 yd td, and if he did that once I'd be thrilled with my points.
CMike is honestly most likely to fall victim to a timeshare of all of those. Plus he's the only one sharing the load with TWO other backs...
If CMike was named the starter I'd probably roll with him, but with high stakes on the line, I'll go with opportunity.
Good luck everyone
I don't necessarily agree with this assessment. If Brees sits (which seems plausible) I would doubt whether Hightower sees 20 carries. I could see a scenario where the Jags score early points and force the Saints into pass mode, which could mean more Spiller. I don't have high expectations for Hightower this week, and am benching him for CAP.
Lamar Miller is your riskiest play. I really can't see how you can trust him to even be on the field in the second half of the game.
I think Karlos is a great start and seems like your best play. After him, in my opinion CMike is your next safest play.....followed by Hightower. I think Miller is a distant 4th right now.