I drafted Wayne as my WR2 and considered moving him before Manning's news but now I've changed my mind. Wayne's numbers have been on the decline the past few years with Manning looking for other outlets and spreading the ball around more. Now with Manning out and Collins new to the system, I think Wayne, being the most experienced receiver for the Colts, will be heavily relied on by Collins. I think Wayne is a good buy low candidate that you can can get quite cheaply from a scared owner. The other Indy Colts WRs I'm not so sure about though.
There's the voice of reason in a sea of chicken littles.of course the Colts won't be the automatic Top-5 type of players they have been for so long but their demise is being seriously over thought/assumed. collins will make the team different but its not like he is Matt leinart or derek anderson. And the Colts may not be a good NFL team but even bad NFL teams often have very good Fantasy plays (Browns/Broncos/Raiders, etc).
The fringe players take a huge hit because the offense isn't going to stay out there long enough to give them the opportunities that made them so attractive. But Wayne should be fine and he actually might be BETTER in PPR than he has been the past couple seasons (which is already pretty danged good. He's always top 7 or better in my PPRs). Clark I am on the fence because I can see the idea of him being a security blanket but I can also see him being asked to block more. And clark's game isn't the traditional security blanket role a TE will see because he is up the field as much as anyone.
So, yes, temper expectations with Collie and Garcon and watch closely on Clark, but Wayne is going to be fine FF-wise.
And, if nothing else, if you believe my line of thought, you may as well buy now because if any of these guys are serviceable weekly starts, you KNOW when Manning comes back they all get a huge boost in perceived value.