I think the Jags are underrated, I don't think they are a fluke 2-1, this is a wildcard contender. When healthy though, I think SF is a Super Bowl contender. They aren't fully healty yet on offense (though Purdy being back is a boon) and now Bosa is done.
The Jags pass game is just wildly inconsistent, between Thomas bad hands and questionable routes, Hunter's lack of playing time and playbook knowledge, its not a coincidence that Brenton Strange has been Lawrence's most trusted weapon. That probably stays the case this week, though Thomas is also capable of huge plays.
I feel like the Jags will sell out to stop CMC (to mixed results, probably another high-volume low efficiency game) leaving some big plays down the field for Pearsall.
I think Vegas has this one pretty on the nose. 49ers eke out a win.