Losing Hunter will hurt long-term, but this week, I think its not a big deal, the Raiders are really awful. 
The Raiders get Brock Bowers back finally, and I expect him to hit the ground running, as the Jags pass rush is likely to destroy any chance of a deep passing game, and the Jags very good run defense (getting Devin Lloyd back) likely erases Jeanty. 
For the Jags, its as simple as can they block Crosby? I think they'll be able to, as the Raiders have nobody else to really be worried about. This is as bad a back 7 in the NFL. I don't know that Brian Thomas suddenly plays great with Hunter out, but I think there will be chances. I do think Etienne has a nice game coming out of the bye, and I think Lawrence could as well, specifically with his legs (also a way to combat Crosby)
Jaguars-24
Raiders-17