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*** Official MONKEYPOX Thread *** - over 30k cases globally / 1st US Death (immunocompromised) (1 Viewer)

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Insoxicated
Here we go... cases doubling but still a very small number.

Exising Smallpox vaccines thought to provide 85% protection (good news).

Two strains with wildly varied CFR.... seems the less fatal version is taking hold in EU (good news).

Nice to see the Anti-Vaxxers are ahead of the curve with the disinformation / resistance. Might as well start politicizing this one before it's even out of the gate. 🤦‍♂️

:popcorn:

IMPORTANT LINKS:

WHO Fact Sheet on Monkeypox >

Our World In Data Dashboard >

Decent Overview Infographic >
 
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[icon] said:
Are you speaking in terms of CFR or Overall case count? 
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https://www.popsci.com/health/monkeypox-who-cdc-outbreak-investigation/

People catch monkeypox after contact with the lesions themselves, or with fluid from them. Public health agencies have also described the virus as spreading through respiratory droplets, which McCollum says is because those lesions often begin on the face or in the mouth and throat, infecting saliva. Those droplets don’t spread very far, so the transmission looks nothing like SARS-CoV-2. “I don’t want the general public to be concerned about going to the grocery store and walking beside somebody and catching monkeypox. That’s really not a situation that has ever been seen before, nor is there any indication it is occurring now.” 
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So far, however, the WHO says it has turned up no evidence that there’s anything new about the genetics of this virus.
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Still, human factors could just as easily explain the outbreak—and seem more likely with the announcement of the two superspreading raves. “I know there’s going to be a lot of scientific questions around this to get at precisely what is occurring,” says McCollum. “I do think that what we’re seeing right now is consistent with what we know about monkeypox.”

That’s because many of the early patients were men who reported recently having sex with other men, and were identified at sexual health appointments. That common behavior also hinted at a transmission route. Last week, the WHO and European CDC both began to narrow in on sexual contact as a possible driver of the outbreak. “We want to be really careful not to stigmatize a specific group,” McCollum says. “This virus can equally affect all genders—what we’re getting at here is close contact.”
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Unless you're having copious amounts of unprotected sex  I think we'll all be safe. 

 
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Update: 13K cases globally. 1.9K in the US. :ph34r:  

Out of the ones who reported gender (1,480), only 17 females. 

 
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Runkle said:
No one under 50 is vaccinated against smallpox, right?
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Pretty much. According to this site:

Routine vaccination of the American public against smallpox stopped in 1972 after the disease was eradicated in the United States. Until recently, the U. S. government provided the smallpox vaccine only to a few hundred scientists and medical professionals who work with smallpox and similar viruses in a research setting. After the events of September and October, 2001, however, we have taken extensive actions to improve our level of preparedness against terrorism. For smallpox, this included updating a response plan and ordering enough smallpox vaccine to immunize the American public in the event of a smallpox outbreak. The plans are in place, and there is sufficient vaccine available to immunize everyone who might need it in the event of an emergency.

 
Paediatric monkeypox patient with unknown source of infection, the Netherlands, June 2022

A boy in the Netherlands contracted monkeypox in June, despite having no discernible contact with a known case. Dutch officials worked hard to try to figure out how the unidentified child, under the age of 10, became infected. They even tested him for a range of sexually transmitted infections and conducted a careful interview to rule out the possibility that he might have been sexually abused. “Extensive source and contact tracing did not identify a potential source,” the investigators who worked on the case wrote in a report to the online journal Eurosurveillance that was published yesterday. 

Health authorities who hope the expanding monkeypox outbreak can be stopped have pointed to the fact that the vast majority of known cases have occurred in gay and bisexual men who have multiple or anonymous partners. But others have warned it is only a matter of time before the virus moves beyond that demographic group.

 
Nathan R. Jessep said:
Update: 13K cases globally. 1.9K in the US. :ph34r:  

Out of the ones who reported gender (1,480), only 17 females. 
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Following the HIV pattern - almost exclusively spreading among gay males by sexual contact (interestingly of those with monkeypox 41% have HIV as well).  If those guys could be monogamous for a month this could be stopped pretty quick.

 
Sand said:
Following the HIV pattern - almost exclusively spreading among gay males by sexual contact (interestingly of those with monkeypox 41% have HIV as well).  If those guys could be monogamous for a month this could be stopped pretty quick.
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That could in theory turn out to be true, but I don't think we can make that conclusion yet. I think that's just the demographic it has shown up in at this point. 

The study this article looked at was a small relative number out of the worldwide case load at this point (less than 5% if my math is correct). We also don't know (I didn't read the study so maybe it states) what populations they surveyed to get that number.  For instance, if they ONLY surveyed homosexual males in certain areas...

Led by scientists at Queen Mary University of London, the new paper looked at 528 confirmed infections in 16 countries, between April 27 and June 24, 2022.

"It is important to stress that monkeypox is not a sexually transmitted infection in the traditional sense; it can be acquired through any kind of close physical contact," said first author John Thornhill, in a statement.

I can't find it now, bc I get a bajillion newsletters and watch several science/med instagram stories, etc. but saw one just yesterday saying that it was very unfortunate that the Monkeypox spike happen to hit during Pride month and how it would tilt the narrative that it was a more sexually transmitted disease than it actually is. I'll post a link if I can dig it back up. 

 
31K globally

The U.S. declares monkeypox a public health emergency

U.S. moves to stretch out supplies of monkeypox vaccine - The FDA issued an emergency use authorization that permits people delivering the vaccine to use fractional doses — one-fifth of a full dose — via intradermal vaccination to people 18 and older. Fractional dosing has been used in the past in times of vaccine shortages; intradermal administration — depositing the vaccine into rather than under the skin — has been shown to generate strong immune responses with smaller amounts of vaccine than are used in vaccine doses administered under the skin or into a muscle.

oh and university campuses prepare for another outbreak - Colleges and universities still dealing with the reality of Covid-19 now have to prepare for the arrival of monkeypox as students stream back to campus for the fall semester. Five campuses — Georgetown University, George Washington University, the University of Texas at Austin, Bucknell University, and West Chester University — have already confirmed monkeypox cases this summer, even with most students away.
 
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I mean it's pretty easy to see how this thing is going to go bananas once college starts back and spread from there. Getting shots to college kids should be goal #1.

John Oliver had a good show on this last week.
 
great info as usual from YLE: How effective are MPX vaccines?

Vaccines will help control the monkeypox (MPX) outbreak. The bad news is that we desperately need more doses. And we don’t know how much the vaccines help and in what manner they help (prevention, duration of disease, severity of disease). This information is absolutely essential so people know how well they are protected and what behaviors they should (or should not) change. This information will also have major implications for controlling the outbreak worldwide.
 

Texas confirms first U.S. death in monkeypox outbreak, says patient was "severely immunocompromised"

Health officials in Texas announced Monday they are investigating what role monkeypox played in the death of a patient who was diagnosed with the virus. State officials said in a statement that the adult patient was "severely immunocompromised."

The patient's death is the first publicly reported by health authorities in the U.S. during the current monkeypox outbreak. However, health officials cautioned that it was too early to say for sure exactly what role monkeypox actually played in the death.

"This is the first death in an presumed positive for monkeypox that we are aware of. However, the individual had various severe illnesses and until the investigation is complete, it is premature to assign a specific cause of death," CDC spokesperson Scott Pauley said in a statement.
 
yourlocalepidemiologist.substack.com

Remember monkeypox? It may be back in headlines

Remember monkeypox? Well, it’s now known as “mpox.” And you may start seeing it pop up in the news again. We have learned a lot since the massive outbreak last summer, but still have a lot of unanswered questions. Here’s what you need to know, particularly going into Pride month.
yourlocalepidemiologist.substack.com yourlocalepidemiologist.substack.com

Last summer’s U.S. outbreak largely concluded by winter, resulting in a beautiful bell-shaped curve below. We would get a few cases a week, but nothing explosive. Containment was largely attributed to grassroots organizations: engagement, testing, and vaccination.​
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However, last month the CDC identified a new cluster of mpox cases in Chicago. CDC has also reported remnants of mpox in wastewater, without linked cases, meaning it’s likely spreading undetected. The Western Pacific has an uptick in cases, and the U.K. just reported an outbreak of 10 new cases in London, too.​
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Combine this with changes in behavior during Pride month, and we may be on the cusp of an outbreak. The CDC thinks the likelihood of this happening is “substantial.”​
 
Don't know much about MPox but Covid just ripped through my house for a second time. It was just as bad for all of us surprisingly. Anyway, good luck with your health everyone.
 
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