Are you basing your prediction on the long historical precedent of teams resting starters in Week 16, including the '09 Colts and ... um ... no one else?
I'll put a stake in the ground and say that it absolutely will not happen. Maybe if they get out to a huge lead, they won't play the fourth quarter. Maybe if a key player gets dinged up (a la Romo in 2011), they'll pull him in a situation where he otherwise might try to gut it out. But zero chance any healthy starters get pulled at the half, much less after one series.
But hey, if you want to sit McCoy against one of the worst running defenses in NFL history, go ahead.