Yeah, this one has blowout written all over it. If I'm the Titans, I'm employing a very run heavy gameplan. Like, even if they are down multiple scores, run the ball. You aren't gonna develop Cam Ward by getting him killed. This game plan should be built around Tony Pollard (perhaps a trade showcase?)
Indy should be able to do mostly what they want. For whatever reason Tyler Warren is the best player in the NFL in the 1st quarter, and then mostly a non-factor thereafter. Sure would be interesting if they kept feeding him for an entire game. Taylor should eat, but I do think/wonder if the Colts maybe start resting him a little later in games like these. Not that you obviously don't start him, but its something that could start to happen. I think Alec Pierce is a decent bye week dart throw as he's been pretty consistently getting deep most weeks, and has been seeing more than just deep targets too. If Josh Downs is needed he'll be great, but he only plays in 3-WR sets, so the upside is limited. Its unfortunate, because he's probably their best WR, sort of the Jayden Reed dilemma.
Colts cover with ease.