Is cologuard every 10 yr offset with 5 yr from the real deal a possible endpoint?
I don’t understand what you’re asking, but in general, Cologuard’s problem is it misses too many precancerous polyps. The screening interval of every three years is based on minimizing the risk a new polyp transforms into a cancer that can’t be easily treated.
So you have to decide if the small risk/inconvenience of endoscopic screening outweighs the (also small) risk a bad polyp kills you.
Now, you can mitigate this risk by doing cologuard more frequently, but then you're increasing the chance you get a false positive = colonoscopy anyway.
AFAIK, there isn’t a well studied protocol of mixing/matching the tests at different intervals.