CurlyNight
Footballguy
One property owner of an investment company on CNN is telling restaurants to pay employees instead of rent. Clay Young in AK.
Oh OK. I don't want to rain on your parade, but as a health care provider I approach miracle cures with cautious optimism and a lot of skepticism. Hopefully this pans out.Nope, not at all. I'm glad someone here has the knowledge to provide context and answers to the natural questions I and everyone would have about these hopeful reports.
It'll be awhile until a big announcement from the FDA. Clinical trials need to happen on even the 50 yo drug I would think. I can't imagine docs willing to risk just rxing that drug. If it causes issues in that pt, he'll get sued or worse.Thanks
While I'd like it to be bigger than self tests, if it helps lessen the burden on healthcare workers, it's still a step in the right direction.
I'd be worried if it's the real deal. Lots of fake stuff out there.My thought was for $36, why the heck not. I wasn't going to start popping them. But it would have been a nice hail mary option to have on hand in the event of the unthinkable.
I’m hear to represent big pharma, and have spent 25 years in drug development. I’m also familiar with commercial drug supply chains.I know Pharma has perpetuated a lot of evil, but I'd be shocked if their is any kind of conspiracy to suppress research into treatment options. Even cheap ones.
Vaccine development will push on regardless. Prevention is arguably more important than treatment.
Oh OK. I don't want to rain on your parade, but as a health care provider I approach miracle cures with cautious optimism and a lot of skepticism. Hopefully this pans out.
My heightened optimism comes from the extraordinary circumstances. If there's ever a time to jump over some barriers, this is it. And since I'm already seeing that barrier jumping begin, it gives me reason to expect the barriers to continue to be pushed aside. Some countries are using this drug as their primary treatment. Some countries are using it on active CV19 patients as a "why not" course of action. If it keeps working in those places, there's simply no way the US gov't can stop it's use here for very long.It'll be awhile until a big announcement from the FDA. Clinical trials need to happen on even the 50 yo drug I would think. I can't imagine docs willing to risk just rxing that drug. If it causes issues in that pt, he'll get sued or worse.
You may see it given to critically ill patients, as a therapeutic Hail Mary, until more clinical data surfaces.It'll be awhile until a big announcement from the FDA. Clinical trials need to happen on even the 50 yo drug I would think. I can't imagine docs willing to risk just rxing that drug. If it causes issues in that pt, he'll get sued or worse.
Grace Fusco — mother of 11, grandmother of 27 — would sit in the same pew at church each Sunday, surrounded by nearly a dozen members of her sprawling Italian-American family. Sunday dinners drew an even larger crowd to her home in central New Jersey.
Now, her close-knit clan is united anew by unspeakable grief: Mrs. Fusco, 73, died on Wednesday night after contracting the coronavirus — hours after her son died from the virus and five days after her daughter’s death, a relative said.
Four other children who contracted coronavirus remain hospitalized, three of them in critical condition, the relative, Roseann Paradiso Fodera, said.
Mrs. Fusco’s eldest child, Rita Fusco-Jackson, 55, of Freehold, N.J., died Friday; after her death, the family learned she had contracted the virus. Her eldest son, Carmine Fusco, of Bath, Pa., died on Wednesday, said Ms. Paradiso Fodera, the family’s lawyer who is Mrs. Fusco’s cousin and is serving as a spokeswoman.
...
Yep. There are many examples of drugs that looked great in pre-clinical studies, but later were shown to have serious toxicities in human trials or worse, postmarketing surveillance.I’m hear to represent big pharma, and have spent 25 years in drug development. I’m also familiar with commercial drug supply chains.
There is no conspiracy here. Existing options including Chloroquine are being studied. One major source of confusion is that all drugs in human clinical trials show some efficacy in models/in vitro/in animal studies. Human trials outcomes are completely different.
Yep, cut from Dr. Lowe’s article.Yep. There are many examples of drugs that looked great in pre-clinical studies, but later were shown to have serious toxicities in human trails or worse, postmarketing surveillance.
Fortunately, we already have safety data for chloroquine/HCQ.
Do you have a link to this assumption regarding China and South Korea?Not sure, wouldn't be surprised.
This all started because in China or South Korea (could've been both) they decided to basically try every known safe drug on CV19 patients to see what might work. And the winner was chloroquine and it's offspring hydroxychloroquine.
Obviously, things work a little differently here.
Absolutely not. Already gonna be chaos. This will turn into The Purge if we let the criminals looseShould we empty out our prisons and let convicted felons loose?
Shader is correct. Any “treatment” will have minimal impact on the spread of COVID-19Do you have a link to this assumption regarding China and South Korea?
Everything I’ve read stated that extensive testing and quarantine procedures are what helped those two countries.
100% in agreement. But as things are falling apart, it’s natural for non-experts to hope there are medical miracles on the way.Getting way too much of a Contagion/Forsythia vibe here people. Calm down a bit and let the professionals do their thing.
I was reading about why vaccines and cures must be tested for months, as many people seem to think we should just immediately roll them out. But when 95-99% of people don’t die from this virus, we can’t put those 95-99% of people at risk with hurtful treatments.Oh OK. I don't want to rain on your parade, but as a health care provider I approach miracle cures with cautious optimism and a lot of skepticism. Hopefully this pans out.
This is particularly the case with a vaccine, which would presumably be given to billions of heathy patients100% in agreement. But as things are falling apart, it’s natural for us to hope there are medical miracles on the way.
I was reading about why vaccines and cures must be tested for months, as many seem to think we should just try them out. But when 95-99% of people don’t die from this virus, we can’t put those 95-99% of people at risk with hurtful treatments.
Is that more or less the reasons why we have to follow strict procedures, even when it seems like we need to quickly push out treatments?
Yep.100% in agreement. But as things are falling apart, it’s natural for non-experts to hope there are medical miracles on the way.
I was reading about why vaccines and cures must be tested for months, as many people seem to think we should just immediately roll them out. But when 95-99% of people don’t die from this virus, we can’t put those 95-99% of people at risk with hurtful treatments.
Is that why we have to follow strict procedures, even when it seems like we need to quickly push out these potential treatments/vaccines/cures?
It's available for compassion use for C-19 patients who are mechanically ventilated. There is in vitro and animal data that makes it look promising for SARS and MERS, but human data for COVID-19 Is extremely limited. Ongoing trials reportedly aren't going so well.Anyone know more about the use of Remdesivir to treat cv19? Is it more promising than Chloroquine - which looks really promising based on the last few pages?
https://www.nih.gov/news-events/news-releases/nih-clinical-trial-remdesivir-treat-covid-19-begins
Stick around Whyatt. You are most welcome here.I’m hear to represent big pharma, and have spent 25 years in drug development. I’m also familiar with commercial drug supply chains.
There is no conspiracy here. Existing options including Chloroquine are being studied. One major source of confusion is that all drugs in human clinical trials show some efficacy in models/in vitro/in animal studies. Human trials outcomes are completely different.
Not to be a downer but I don’t think it’s made in the US. I believe that the NJ company just distributes the drug which is made in China. After having a patient insistent in having a drug ‘not made in China’, I found out how rare it was.And thankfully as I just found, it's produced in the US by at least one domestic drug company in New Jersey...
https://www.cdc.gov/malaria/new_info/2016/chloroquine_shortage.htm
https://www.drugs.com/manufacturer/rising-pharmaceuticals-inc-218.html
This is the second case of “I do what I want” I’ve seen come out of LA. Don’t understand it and for those in attendance, good luck, hope you got what you needed out of that service. Now stay away from everyone for the next two weeks. We literally have a case study of how this works out ala South Korea. They can almost with 100% accuracy trace their outbreak back to the cult who kept meeting after members where showing signs of sickness.Pastor defies coronavirus ban as hundreds attend church
A Louisiana pastor held a church service Tuesday night with hundreds of congregants despite an order from the state's governor banning gatherings of more than 50 people. The pastor, Reverend Tony Spell, told CBS affiliate WAFB that the coronavirus, which has killed at least 109 people in the United States, is "not a concern."
Chloroquine hasn't been prescribed much for malaria for a long time. Most malaria in the world became resistant to it long ago. I was prescribed chloroquine in 1994 for Guatemala and that is the last time I've heard of someone being prescribed it.Not to be a downer but I don’t think it’s made in the US. I believe that the NJ company just distributes the drug which is made in China. After having a patient insistent in having a drug ‘not made in China’, I found out how rare it was.
From my anecdotal experience, chloroquine is not readily available, in fact any time I’ve tried to order it’s been out of stock. That’s not saying that they can’t ramp up production if needed, it’s just not a common drug here.
On the other hand hydroxycholoroquine and azithromycin are very much available. These studies are highly encouraged but I’m firmly on the skeptical but hopeful side.
I remember taking Chloroquine against Malaria in the 90'ies. That was pretty rough on the stomachYou may see it given to critically ill patients, as a therapeutic Hail Mary, until more clinical data surfaces.
Hydroxychloroquine has potential side effects, so it isn't entirely benign. These include retinal and heart toxicity, though these appear to be more of a problem with chronic use.
Yeah, the most common side effects are gastrointestinal distress and blurry vision, but they're not usually serious. There's a ton of other stuff that occurs less commonly.I remember taking Chloroquine against Malaria in the 90'ies. That was pretty rough on the stomach
There are only a few pockets of chloroquine-susceptible malaria left in the world. Reduced demand has probably led to decreased production of the drug, though I'm not certain.Chloroquine hasn't been prescribed much for malaria for a long time. Most malaria in the world became resistant to it long ago. I was prescribed chloroquine in 1994 for Guatemala and that is the last time I've heard of someone being prescribed it.
All those vitamins/minerals/supplements may be helpful, but none have been tested rigorously. Eating a diet rich in fruits and veggies +/- vitamin D, if deficient/insufficient (pretty common in the US), is likely all you need.Potential interventions for novel coronavirus in China: A systematic review
https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.25707
Gets pretty sciencey but an interesting read... stuff we can take right now:
1) Vitamin A - no need for supplement, should come from healthy diet. Sweet potatoes, carrots, eggs, spinach, etc.
2) B Vitamins ... B2, B3, B6. No need to go crazy here, but bi-weekly doses are what I'm doing.
3) Vitamin C - again, should come from diet. Nothing wrong supplementation.
4) Vitamin D - get sun if you can, I take 5000 IU everyday.
5) Vitamin E - I take it 1-2x per week. Should find a quality brand/supplement for this one.
6) Fish oil
7) Selenium - I take 200 mcg nightly.
Zinc - I take 15 mg nightly.
I also take 300-400 mg magnesium glycinate every night. Its not on this list but I think its important for everything.
A note on those who take curcumin / turmeric supplements. Keep in mind, there are very few studies on what I'm about to say so take with a grain of salt. Proper iron levels are important for COVID-19 (not too high/low, see linked study), curcumin has been shown to impair iron status in rats and there is a case study in a human too. Curcumin may also increase expression of the ACE2 receptor (Angiotensin‐converting enzyme‐2). ACE2 may be the main receptor mediating virus entry into the cell. Search MedCRAM on youtube, very good videos on COVID-19 from a doctor.
These stories as well as the Spring Break ones just show that this isn’t going to work when not everyone listens. I just don’t see how w avoid the spread of it.This is the second case of “I do what I want” I’ve seen come out of LA. Don’t understand it and for those in attendance, good luck, hope you got what you needed out of that service. Now stay away from everyone for the next two weeks. We literally have a case study of how this works out ala South Korea. They can almost with 100% accuracy trace their outbreak back to the cult who kept meeting after members where showing signs of sickness.
Our church, like all the others around here has gone virtual for minimum of 2 weeks. If yours hasn’t, I’d seriously ask your leadership why not?
Agreed. The pressure on hospitals to provide care/beds is the biggest issue. If we aren't turning hotels into ICU wards immediately then (IMO) there is very little that we will be able to do to handle this. We are going to have a lot of people get sick and a lot of older people be in real trouble. And this will bring on even further shut downs, more panic and unrest and it can quickly unravel.These stories as well as the Spring Break ones just show that this isn’t going to work when not everyone listens. I just don’t see how w avoid the spread of it.
My MIL takes it for rheumatoid arthritis. She has been prescribed this for 24 years.Chloroquine hasn't been prescribed much for malaria for a long time. Most malaria in the world became resistant to it long ago. I was prescribed chloroquine in 1994 for Guatemala and that is the last time I've heard of someone being prescribed it.
I was 100% sure this would happen. We have a portion of the population that just won't listen.These stories as well as the Spring Break ones just show that this isn’t going to work when not everyone listens. I just don’t see how w avoid the spread of it.
I saw a news report that said the National Guard paid this pastor a visit and explained that they would have no hesitation in shutting him down if he tried this again.These stories as well as the Spring Break ones just show that this isn’t going to work when not everyone listens. I just don’t see how w avoid the spread of it.
Could you please link that study? I don’t see how China could have halted the spread if 86% of cases went unreportedHad trouble sleeping last night, I’m sure that’s common these days.
One thing I kept thinking - I’d that study was correct in saying that in China as many as 86% of cases went unreported - not only does that mean the actual death rate is actually lower - but also that the spread of this thing is far worse than we thought. If that’s the case, and with Americans being pretty reluctant to self isolate, or at least to the point of it being effective for the collective whole - the odds of our plan working seem slim.
pelotonFor folks who have gym memberships, just a reminder to freeze those and save a few bucks -- I doubt most of us will be going to the gym for a while, if your gym is even still open at this point. Score one for the home gym folks.
As a small fitness studio business owner - I understand your point BUT if your membership isn’t a burden on your family budget consider letting it run.For folks who have gym memberships, just a reminder to freeze those and save a few bucks -- I doubt most of us will be going to the gym for a while, if your gym is even still open at this point. Score one for the home gym folks.