I would definitely recommend a trip to Denver for the activies that you are looking for. If I were you, I would probably stay in downtown Denver for two nights, as there are a number of world-class breweries and brewpubs in downtown Denver. My personal favorite brewpubs are
Freshcraft and
Falling Rock Tap House, both of which offer an unbelievable selection of beers from local Colorado breweries and other top breweries around the world. You should also definitely visit
Great Divide Brewing Company, which is one of the top microbreweries in the world and is located in downtown Denver. Actually, I would recommend renting bikes in downtown Denver and then doing a self-guided brewery tour in Denver, in which you can easily bike to numerous great breweries within a mile radius around town, including Great Divide, Denver Beer Company, Wynkoop Brewing Company, River North Brewery, Renegade Brewing Company, Prost Brewery, and Strange Brewing Company. I've done this a few times, and it is always great fun and a great way to see the sights of Denver.
I would also definitely recommend renting a car and then taking a drive up I-70 into the mountains to stay for a few days. The 1.5 hour drive on I-70 from Denver up to the ski resort towns of Vail/Beavercreek is one of the most beautiful drives in the country. Stunning views of the Rocky mountains. Depending on what time of year you go, there are a wide variety of hiking/snowshoeing trails all along I-70. If you want, I can probably recommend some specific trails to you depending on the season. It would probably be fun to stay in one of the ski resort towns like Vail for a couple days, as your wife would probably enjoy walking around the town, there are numerous bars in town, and there are plenty of outdoor activities that you can do from there (biking, snowmobiling, hiking, etc.).
Also, if you really want to get a full beer tour in your trip to Colorado, I would also recommend heading up to Ft. Collins to visit some of Colorado's finest breweries. I am a huge fan of
Odell Brewing Company. You should also check out New Belgium and Ft. Collins breweries if you are heading up there.
I would also recommend taking a drive through Rocky Mountain National Park for some amazing views of the Rockies and wildlife. RMNP is about 1.5 hours from Denver and probably less than that from Vail, although it will depend what roads are open at the time you visit. You can do some great hiking/snowshoeing there. You can also stop by the Oskar Blues breweries in Lyons or Longmont, both of which are fairly close to RMNP.