I hate to say it, but it almost has to be an assistant coach question because there are too many variables involved. Roster size, number of teams, starting requirements, size of offseason rosters, scoring system, transaction rules, your team's record, your team's likely chances this year and next, your current collection of draft picks, the positions of strength on your team, the age of your starters, future value on your roster... there's too much that makes a big difference to make general strategy statements IMO. So, I'll do it anyway:Roster size/number of teams/starting requirements: The bigger the rosters, the worse stuff is available on the wire, but that's always true, so this is a good time to scour for possible offseason promotions... Ajirotutu, Whitehurst, Sutton, Shipley, Tarvaris Jackson, Jordy Nelson, Kolb, McGahee, Olsen, Hart, Hardesty, BenTate, Maualuga, Angerer, Dillard, Lee, the LB on San Diego whose name I can't think off, Edds are some guys who could have a spike in value this offseason for various reasons but could possibly be available depending on how deep your league's rosters are. There's also a component of how many starters - if you have 16 teams with shallow rosters, a starting QB is worth more than in a 12-team league with larger rosters. If you can start 2 RBs and one flex, it drives up RB value and makes digging for possible future starters more important.Size of offseason rosters: If you have to cut down to a staring lineup plus 10 bench spots, it doesn't really matter how large your in-season rosters are since you're not going to be keeping the guys anyway. In that case, just go for the best depth you can this season for the most part.Scoring system: PPR is a big one, of course - without it, the incentive to consider undersized receivers goes down. Much the value interaction between the positions relies on this - 4/pass drives down the need to look for QB depth, 2 PPR for TEs makes them more attractive... on the IDP side, this can be huge - give a big bonus for sacks at an already thin DE position and it makes the Graham, Dunlap, Hughes, EBrown, etc. into great guys to stash.Transaction rules: Obviously transaction costs drives up the cost of taking chances on players, whether it's real money or league money. If your league cuts off waivers really early, you might ignore future prospects to get depth at PK before the playoffs.Your team's record: This affects other people's opinions of your draft picks if you're looking to trade. If you're 10th in scoring but 4-4, you're better off holding on to your picks because other people will see you as a middle-of-the-pack team, while in reality you're more likely to go 1-4 from here on out and get an earlier pick than others think.Your team's likely chances this year and next: If you have a shot at a title, that has to be a major weight in the decision. Win a title, then work for next year in the offseason. Think of next season also - if you're not going to win this year because you have Romo, Grant, RMoss, and DWilliams, but you think they'll rebound enough next season, don't tear up your roster.Your current collection of draft picks: I've got a league where our offseason rosters are 53, then expand to 60 at rookie draft time... and I've got 12 draft picks right now. That drives me to think about paying for help this season rather than looking to next season, since accumulating more draft picks gives less of an advantage than it might. It also means I don't look as strongly at waiver wire guys because I'm unlikely to keep them through next offseason.The positions of strength on your team: I've got a league where there are always good safeties on the waiver wire... and I've got six really good safeties. There's no real point in spending much time looking at the guys on the wire.The age of your starters: If you've got McFadden, McCoy, Mendenhall, Foster, and Wells, you don't need Portis as well... but you also don't necessarily need to look as strongly at RB prospects and can focus on WRs.Future value on your roster: If you've got guys who aren't startable this year, but will be in the future (Mathews, Spiller, Hardesty, Crabtree, Bradford, Demaryius, etc.), there might be an incentive to sell an older player off knowing you won't need him as much in the future.