You gotta go QB,QB with the first 2 pic's,
If you don't there will be nothing left to get.
My main league is Supeflex with QB being a player you can use in the flex spot.
After round 3 there are virtually no QB's worth rostering left, your 3rd/backup QB is basically a bye week filler for the other 2.
(and everyone takes 3 QB's, so nothing left on the waiver wire either)
This kind of league is tough to do with more than 10 owners, 10 it's not bad, the more owners the more you better get 2 good QB's.
(if it is a new league and or 1st time doing the 2 QB scenario you will have some owners sleeping on the format, and that helps)