Notable deaths from use
Purple drank is confirmed or suspected to have caused the deaths of several prominent users. Respiratory depression is a potentially serious or fatal adverse drug reaction associated with the use of codeine, but mainly the danger lies in the much more potent and CNS-depressing phenothiazine-related antihistamine promethazine. This depression is dose-related and is the mechanism for the potentially fatal consequences of overdose: respiratory or cardiac arrest. As with most CNS depressants, mixing with alcohol greatly increases the risk of respiratory failure and other complications.
DJ Screw, who popularized the codeine-based drink, died of a codeine-promethazine-alcohol overdose on November 16, 2000, several months after the video to Three 6 Mafia's single debuted.[6]
Big Moe, a DJ Screw protegé whose albums City of Syrup and Purple World were based on the drink and who has been described as having "rapped obsessively about the drug,"[19] died at age 33 on October 14, 2007, after suffering a heart attack one week earlier that left him in a coma.[20] There was speculation that purple drank may have contributed to his death. [14][21]
Pimp C, widely influential Port Arthur, Texas rapper and a member of rap duo UGK, was found dead on December 4, 2007, at the Mondrian Hotel in West Hollywood, California. The Los Angeles County Coroner's office reported that the rapper's death was "due to promethazine/codeine effects and other unestablished factors." Ed Winter, assistant chief of the coroner's office, said the levels of the medication were elevated, but not enough to deem the death an overdose. However, Pimp C had a history of sleep apnea, a condition that causes one to stop breathing for short periods during sleep. A spokesman for the coroner's office said that the combination of sleep apnea and cough medication probably suppressed Pimp C's breathing long enough to bring on his death.[3][19]