Scoresman
Footballguy
That is insane. You’d think all the years of medical school and experience treating people would wash away all that stupid, but I guess there’s just no helping some.
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*** OFFICIAL *** COVID-19 CoronaVirus Thread. Fresh epidemic fears as child pneumonia cases surge in Europe after China outbreak. NOW in USA (9 Viewers)
- Thread starter Big League Chew
- Start date
- Status
Nathan R. Jessep
Footballguy
No infectious disease has been politicized like this before. At least in most of our lifetimes. That is almost assuredly the reasoning.
Leeroy Jenkins
Footballguy
Anyone find an updated shot yet? Rite Aid still says “coming soon” like it’s a summer blockbuster.
Osaurus
Footballguy
I have Walgreens in the Tampa area scheduling for Wednesday and beyond with updated boosters. I’m slated for Friday with a flu shot as well.
Leeroy Jenkins
Footballguy
I got a walgreens appointment for the Pfizer updated shot for Friday. If Moderna pops up at rite aid earlier, I may switch it.
But if you really are looking to take the useless garbage, then this is for you:
margaretannaalice.substack.com
50 Reasons to Give Your Child the COVID Shot
Are you wondering if it’s a good idea to give your kid the COVID shot? I know there’s an ocean of mis/dis/mal/information out there to navigate, so I’ve compiled this handy list of reasons you’ll want to rush your child to the nearest injection site stat.
margaretannaalice.substack.com
Capella
Footballguy
Haven’t seen it near me yet.
Osaurus
Footballguy
It’s out there at Walgreens starting Wednesday. I’m getting mine Friday.
Leeroy Jenkins
Footballguy
Not my kid’s class, but after just one week of school there was a kindergarten teacher and aid who both tested positive. My friend’s son caught it from them and spread it to the whole house.
Nathan R. Jessep
Footballguy
One shot per year? We really need to step up our game then
Yesterday, the White House announced a new plan: one COVID-19 shot per year. The idea is this will decrease public confusion and increase booster uptake by aligning with the flu vaccine campaign. Reading between the lines, I think this is also a political signal to shift out of the SARS-CoV-2...
yourlocalepidemiologist.substack.com
and what stands out to me...her thoughts on treating this like the flu right now:
SARS-CoV-2 is mutating 4 times faster than the flu. It’s not seasonal nor annual. It’s not mutating in a ladder like form. And we do not have global surveillance systems in place. We expect and hope that COVID-19 will eventually be like the flu but to assume that has already happened is premature. I also think it is a gamble, as the virus continues to surprise us. To pivot the public—again—is risky.
Nathan R. Jessep
Footballguy
well, um, this could thwart the progress of the pan-vaccines and nasal vaccines... MFers!
www.statnews.com
Pfizer isn’t sharing Covid vaccines with researchers for next-gen studies
Researchers studying next-gen vaccines to fight an evolving Covid threat are running into problems getting existing vaccines to use in their research.
www.statnews.com
Doug B
Footballguy
well, um, this could thwart the progress of the pan-vaccines and nasal vaccines... MFers!
Pfizer isn’t sharing Covid vaccines with researchers for next-gen studies
Researchers studying next-gen vaccines to fight an evolving Covid threat are running into problems getting existing vaccines to use in their research.
Pfizer is playing this wrong.
New-vaccine researchers can (and probably will) simply partner with a third party (e.g. a national drugstore chain) to administer mRNA vaccines to their control-group participants. There are plenty of Walgreens and CVS locations nationwide.
What Pfizer (and Moderna) should be doing is buying into these new vaccine efforts. Partner up with some of these smaller companies doing, say, nasal vaccine research. Provide funding for this new research in exchange for a portion of the potential profits later. The Operation Warp Speed money should mean that, for Pfizer and Moderna, a little extra risk is worth taking now for a likely big payoff later.
AAABatteries
Footballguy
Not sure - with apologies to @Zasada, I don't think a separate thread was totally necessary but it also wasn't necessary for the folks taking a dump in the thread. I think discussing the new boosters in here is good.
Zasada
Footballguy
Yeah I was excited to get the booster, and surprised that I missed the news. Figured I could do a PSA for others who were in the same boat as me.
I thought about getting sucked-in to the dumping in that thread (by explaining my rationale), but figured it wasn't worth it. It would have just driven more dumping.
AAABatteries
Footballguy
Yeah I was excited to get the booster, and surprised that I missed the news. Figured I could do a PSA for others who were in the same boat as me.
I thought about getting sucked-in to the dumping in that thread (by explaining my rationale), but figured it wasn't worth it. It would have just driven more dumping.
All good and honestly another thread is no big deal - people aren't starting a lot nowadays anyway. I appreciate the posts about the updated booster as I wasn't aware of it or it coming out except through the threads here. Scheduled mine for Friday along with my flu shot. Good luck!
The Commish
Footballguy
Not sure if you guys are following the antibody research, but a continuation of this research has isolated two different antibodies that are particularly effective at going after both Delta and Omicron variants of the virus' spike protein. If this holds it could mean that antibody treatments become an effective tool along with the vaccines.
Leeroy Jenkins
Footballguy
My kids all had colds over the weekend and this week, and now I have some version of it as well. No fever (and not Covid), but not feeling great. Do I need to cancel my booster for tomorrow?
Nathan R. Jessep
Footballguy
further data on Paxlovid seems to prove the earlier theories:
insidemedicine.bulletin.com
he goes into greater detail, but the tl;dr quote:
And yet droves are taking Paxlovid precisely on the hopes that it hastens symptom resolution. Others are taking Paxlovid hoping to decrease the risk of Long Covid. There is no evidence that Paxlovid either improves symptoms or prevents Long Covid.
and it DOES still provide great results for unvaccinated individuals
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insidemedicine.bulletin.com
he goes into greater detail, but the tl;dr quote:
And yet droves are taking Paxlovid precisely on the hopes that it hastens symptom resolution. Others are taking Paxlovid hoping to decrease the risk of Long Covid. There is no evidence that Paxlovid either improves symptoms or prevents Long Covid.
and it DOES still provide great results for unvaccinated individuals
Doug B
Footballguy
Layman's thought:
You know how the mRNA vaccines contain instructions for our cells to make SARS-CoV-2 spike proteins? And then a healthy immune system reacts by creating antibodies against those spike proteins?
I am curious as to whether an mRNA vaccine can elicit our cells to directly make antibodies? And if so, can it be the two promising antibodies that your link mentions? An antibody is probably a much more structurally complex than the SARS-CoV-2 spike protein, so there's probably a reason this wouldn't work.
PinkydaPimp
Footballguy
Interesting article thanks for sharing. For me when i took it it seemed to get rid of all symptoms(like immediately) then delay the bigger symptoms. I have no way of knowing if they would have been worse without it or if it simply delayed the inevitable.further data on Paxlovid seems to prove the earlier theories:
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he goes into greater detail, but the tl;dr quote:
And yet droves are taking Paxlovid precisely on the hopes that it hastens symptom resolution. Others are taking Paxlovid hoping to decrease the risk of Long Covid. There is no evidence that Paxlovid either improves symptoms or prevents Long Covid.
and it DOES still provide great results for unvaccinated individuals
The Commish
Footballguy
I'm not sure we'd want to do that. The thymus has an incredibly complex series of events it goes through to ensure the t-cells it produces are not harmful to the body. I don't think we want human intervention in that process. It's much safer to create the protein and let the immune system do its thing.
Dezbelief
Footballguy
I am waiting for the little bit of congestion I have to clear before getting my booster.
Scoresman
Footballguy
Are you relying on home tests to determine that its not COVID or did you get PCR?
Leeroy Jenkins
Footballguy
People still do PCRs? I actually have a couple at-home PCRs that I can use before getting the shot.
Doug B
Footballguy
... the next best thing, then, would be mRNA containing instructions for boutique protein structures that would elicit exactly those two antibodies (they have names - TAU-2212 and TAU-2303). It could even be proteins that haven't yet been detected on an actual SARS-CoV-2 virion.
Doug B
Footballguy
Thinking on this some: Monoclonal antibodies used for COVID treatments (the various "-mab"s) aren't processed through the thymus. What would be the difference?
IOW, if the thought is that mRNA-created antibodies might be treated as foreign cells by our immune system ... what keeps that from happening with existing monoclonal antibody treatments?
Doug B
Footballguy
Looking into the bolded: Antibodies are more complex than the spike protein, but by much less than I thought. The theoretical molecular weight for the spike protein is just under 80 kilodaltons (kDa), while that of a monoclonal antibody is around 150 kDa.
Doug B
Footballguy
(NOTE: Recent figures in the Worldometers graphs can get large adjustments as much as two weeks after they first drop. Accordingly, I've waited ten days to let the last-week Monday (August 29) numbers settle in. They will likely rise slightly by next week's update.)
Updating numbers to see where things have been standing recently from a top-of-the-mountain view. All figures below are 7-day averages from Worldometers U.S. graphs here. In the United States:
CASES ON THU 09/08/2022
Thu 01/13/2022 - 826,760 <--OMICRON SURGE 2022 HIGH
Tue 02/01/2022 - 425,029
Thu 02/17/2022 - 116,616
Mon 02/28/2022 - 62,205
Mon 03/14/2022 - 32,900
Sat 04/02/2022 - 27,313 <--2022 LOW
Mon 04/18/2022 - 40,892
Mon 05/02/2022 - 63,279
Mon 05/16/2022 - 100,359
Mon 05/30/2022 - 110,505
Mon 06/13/2022 - 107,785
Mon 06/27/2022 - 113,557
Mon 07/11/2022 - 120,686
Fri 07/15/2022 - 133,047 <-- SPRING/SUMMER SURGE HIGH
Mon 07/18/2022 - 132,635
Sun 07/24/2022 - 132,199
Mon 08/01/2022 - 125,348
Mon 08/08/2022 - 112,032
Mon 08/15/2022 - 102,485
Mon 08/22/2022 - 93,832
Mon 08/29/2022 - 89,486 (est ~80,000 on 9/1/2022)
Tue 09/06/2022 - 64,766 <--provisional count
DEATHS ON THU 09/08/2022
Sun 01/29/2022 - 2,822 <--OMICRON SURGE 2022 HIGH
Fri 02/18/2022 - 2,190
Mon 02/28/2022 - 1,740
Mon 03/14/2022 - 1,105
Mon 03/28/2022 - 623
Mon 04/11/2022 - 487
Mon 05/02/2022 - 338
Sat 05/14/2022 - 284 <--2022 LOW
Mon 05/16/2022 - 289
Mon 06/06/2022 - 341
Mon 06/20/2022 - 318
Mon 07/04/2022 - 369
Mon 07/11/2022 - 396
Mon 07/18/2022 - 422
Mon 07/25/2022 - 444
Mon 08/01/2022 - 452
Mon 08/08/2022 - 504
Thu 08/11/2022 - 511 <--SPRING/SUMMER SURGE HIGH
Mon 08/15/2022 - 487
Mon 08/22/2022 - 460
Sun 08/28/2022 - 428
Mon 08/29/2022 - 424 estimated (349 on Thu 9/1/2022)
Tue 08/30/2022 - 419
Mon 09/05/2022 - 312 <--provisional count
CASES: 7-day average of confirmed COVID cases in the U.S. peaked at 825,929 on 1/13/2022, and was provisionally 89,486 on 8/29/2022. Starting from a peak on July 15, 2022, the 7-day case numbers has continued to decline for eight weeks now. There are signs that the decline may begin to accelerate.
DEATHS: 7-day average of confirmed COVID cases in the U.S. peaked at 2,756 on 1/29/2022, and is estimated** at about 424 on 8/29/2022. The 7-day average deaths on 8/11/2022 is the new spring/summer high, now adjusted to 511. A decline in deaths continues to show in the data. There is a fair chance that the Monday 9/5 number will remain below 400 even after adjustments, which will be something of a milestone.
For comparison: Low-water marks in the U.S. from summer 2021, 7-day averages after the initial thrust of vaccinations and before summer 2021's Delta surge.
CASES: 12,265 on 6/21/2021
DEATHS: 245 on 7/8/2021
** Worldometers' graph, for today, skips a number for 8/29/2022. The 424 is derived by splitting the difference between 8/28/2022 and 8/30/2022.
Updating numbers to see where things have been standing recently from a top-of-the-mountain view. All figures below are 7-day averages from Worldometers U.S. graphs here. In the United States:
CASES ON THU 09/08/2022
Thu 01/13/2022 - 826,760 <--OMICRON SURGE 2022 HIGH
Tue 02/01/2022 - 425,029
Thu 02/17/2022 - 116,616
Mon 02/28/2022 - 62,205
Mon 03/14/2022 - 32,900
Sat 04/02/2022 - 27,313 <--2022 LOW
Mon 04/18/2022 - 40,892
Mon 05/02/2022 - 63,279
Mon 05/16/2022 - 100,359
Mon 05/30/2022 - 110,505
Mon 06/13/2022 - 107,785
Mon 06/27/2022 - 113,557
Mon 07/11/2022 - 120,686
Fri 07/15/2022 - 133,047 <-- SPRING/SUMMER SURGE HIGH
Mon 07/18/2022 - 132,635
Sun 07/24/2022 - 132,199
Mon 08/01/2022 - 125,348
Mon 08/08/2022 - 112,032
Mon 08/15/2022 - 102,485
Mon 08/22/2022 - 93,832
Mon 08/29/2022 - 89,486 (est ~80,000 on 9/1/2022)
Tue 09/06/2022 - 64,766 <--provisional count
DEATHS ON THU 09/08/2022
Sun 01/29/2022 - 2,822 <--OMICRON SURGE 2022 HIGH
Fri 02/18/2022 - 2,190
Mon 02/28/2022 - 1,740
Mon 03/14/2022 - 1,105
Mon 03/28/2022 - 623
Mon 04/11/2022 - 487
Mon 05/02/2022 - 338
Sat 05/14/2022 - 284 <--2022 LOW
Mon 05/16/2022 - 289
Mon 06/06/2022 - 341
Mon 06/20/2022 - 318
Mon 07/04/2022 - 369
Mon 07/11/2022 - 396
Mon 07/18/2022 - 422
Mon 07/25/2022 - 444
Mon 08/01/2022 - 452
Mon 08/08/2022 - 504
Thu 08/11/2022 - 511 <--SPRING/SUMMER SURGE HIGH
Mon 08/15/2022 - 487
Mon 08/22/2022 - 460
Sun 08/28/2022 - 428
Mon 08/29/2022 - 424 estimated (349 on Thu 9/1/2022)
Tue 08/30/2022 - 419
Mon 09/05/2022 - 312 <--provisional count
CASES: 7-day average of confirmed COVID cases in the U.S. peaked at 825,929 on 1/13/2022, and was provisionally 89,486 on 8/29/2022. Starting from a peak on July 15, 2022, the 7-day case numbers has continued to decline for eight weeks now. There are signs that the decline may begin to accelerate.
DEATHS: 7-day average of confirmed COVID cases in the U.S. peaked at 2,756 on 1/29/2022, and is estimated** at about 424 on 8/29/2022. The 7-day average deaths on 8/11/2022 is the new spring/summer high, now adjusted to 511. A decline in deaths continues to show in the data. There is a fair chance that the Monday 9/5 number will remain below 400 even after adjustments, which will be something of a milestone.
For comparison: Low-water marks in the U.S. from summer 2021, 7-day averages after the initial thrust of vaccinations and before summer 2021's Delta surge.
CASES: 12,265 on 6/21/2021
DEATHS: 245 on 7/8/2021
** Worldometers' graph, for today, skips a number for 8/29/2022. The 424 is derived by splitting the difference between 8/28/2022 and 8/30/2022.
The Commish
Footballguy
Monoclonal antibodies have a specific instruction to look for a specific protein. Let me put my concern in nerdy application terms. If a person wants to update their personal information with their employer, we ask them to go to their HR portal and do the appropriate updates, right? We don't expect them to dig into the tons of different "behind the scenes" tables in the different databases where the data is stored and provide manual SQL statements hoping that they get things updated everywhere they need to get them updated. Your first comment I responded to, is a lot more like going into all the different tables and going to the screen is a lot more like introducing the protein. What you asked could likely be done, but there would be a TON of "updates" to do it correctly and a lot of trial/error to understand if it was done correctly. The more instruction that needs to be provided by a vaccine, the more risk we could make a mistake.
Hopefully the babble makes sense.
Doug B
Footballguy
Check this out -- apparently, it doesn't have to be a human thymus. A mouse thymus will do the job as well.
I learned something today: I all thought all the -mab treatments were synthetic and essentially Tinkertoyed in a lab. Similar to the way the mRNA vaccines' RNA packages are assembled.
Instead, the -mabs are true biological products that require living beings (apparently mammals or whatever else has a thymus?) to produce them. One production method which people have heard about is harvesting convalescent plasma from people who've recovered from COVID. I'll bet a lot of the public is not hip to the little mouse-borne antibody factories that have been used since what? - the mid-2000s or so.
I love the names of the proprietary manufacturing platforms: Xenomouse. OmniRat. Kymouse. Sounds like Pokemon.
EDIT: "The thymus is present in all jawed vertebrates." Might be able to have fish-manufactured monoclonal antibodies. Interesting.
The Commish
Footballguy
Correct....the antibodies are actual antibodies, just produced in someone/something other than the host. They are "living" things that were produced in AN immune system somewhere. Mice have very similar immune and cardiovascular systems to humans that's why so much research is done using them.
AAABatteries
Footballguy
Got the updated booster and flu shot this morning - hoping if I feel bad it’s just today.
Doug B
Footballguy
My family of four is going tomorrow for our bivalent boosters.
No one else in the household was eligible ... but I was able to get a second booster (4th shot of original formula) in mid-May. I've been considering delaying my bivalent booster until late October so that the BA.5 protection isn't waning so much by Christmas & New Year's. Of course, right now I'm running off of a four-month old booster ... so maybe it doesn't matter all that much.
No one else in the household was eligible ... but I was able to get a second booster (4th shot of original formula) in mid-May. I've been considering delaying my bivalent booster until late October so that the BA.5 protection isn't waning so much by Christmas & New Year's. Of course, right now I'm running off of a four-month old booster ... so maybe it doesn't matter all that much.
Leeroy Jenkins
Footballguy
I just canceled mine. Not feeling great still here. But now I travel to NYC next week and DC the following week. I was hoping to have the beginnings of that extra protection prior to all of the travel, meetings, and meals. Now I probably will wait a week after I am back from the second trip to make sure I don't have covid (let's hope) before getting the shot.
PinkydaPimp
Footballguy
Plenty of places to get it in NYC if you wanted to get it here.
Leeroy Jenkins
Footballguy
I have been knocked out for 24+ hours after each shot so far. So I need to get it when I can be down for a day and not in meetings.
Osaurus
Footballguy
Bummer. Only the first shot made my arm very sore. The rest were mild to nada.
Nathan R. Jessep
Footballguy
Just curious, was this similar (or identical) to the reaction you fellas got from your last shot?
PinkydaPimp
Footballguy
ah ok. For me only the first two shots(moderna) hit me. The 3rd and 4th didnt really do much other than my arm hurt. But i know it depends on the person.
top dog
Footballguy
Got my booster and flu shots yesterday at CVS. Had an appointment at Rite Aid but when I got there they were like 'Sorry, we didn't get our shipment'. Drove by CVS on the way back home and saw on their sign they were promoting having boosters. Checked with them to confirm they had the updated one and a flu shot and got it as a walk in there. Arm is a bit sore today, but nothing horrible. I know it is somewhat controversial to some people but all I know is I've lost some people that were close to me and it wasn't to the covid vaccine. It was to the actual covid covid. I was vaccinated and boosted at the end of Oct. 2021. When Omicron hit almost everyone around me has had covid at some point including my wife, but I've managed to avoid it unless I was just one of the lucky asymptomatic ones. When she had it I tested regularly that week as I was also helping out getting my father to and from cancer treatments. Regardless, I know the vaccine and booster seems to have helped me out so I'm sticking with what has worked so far. Sign me up for the jab juice. 
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