In another thread it was mentioned that he was considering a political run and axed the account.Do you mean "deleted intentionally", like he asked the mods to dump all of his posts?
Or do you mean "hard banned", somehow? I didn't know anyone ever crossed the line so bad they got their entire forum history erased.
Fauci actually said as much. Soon though!Not to put a damper on the vaccine optimism coming from the declines in the UK and Israel, but I don’t think the improving numbers are due to vaccinations...yet. We’re a month out from the major holiday gatherings, we’re bound to see significant declines no matter the rate of vaccination.
The benefits of vaccinations will come and soon but not yet. Most elderly haven’t received 2nd dose. It will probably take a couple more months before we see the true benefits from the vaccine.
Don’t get me wrong, I’m trying to get as many people vaccinated as possible, just seems way too early to give credit to the vaccine for the drop. Inevitably when you do that, backlash will start if cases start to rise again.
I hope something like this really pans out. Sounds kind of too good to be true. But: if it's basically a souped-up saline solution ... we know that salt/brine is a time-tested antibacterial agent. Could sodium chloride also be an anitiviral on surfaces -- or in this case, on mucous membranes?
I've been waiting for this to be approved
Ah ... this one sounds less than legitimate:I've been waiting for this to be approved
Not sure if same
InvisiMask is a proprietary, engineered human antibody nasal spray that delivers SARS-CoV-2 neutralizing antibodies directly to the nasal passages, where most COVID-19 infections enter the body.
The compound combines the best properties of IgG and IgA. IgG is easy to manufacture but has a shorter half-life in the mucosa. By engineering IgG antibodies to bind to mucins (as does IgA) in the airway epithelium, their half-lives in the mucosa were extended while maintaining its ability to be scaled up easily for commercial manufacturing.
No, I don't think that's the same.I've been waiting for this to be approved
Not sure if same
It's pretty clear that the first shot delivers some level of protection. The 60% figure you mentioned is probably near the consensus.I've read conflicting reports on the first of two vaccine shots? I read somewhere that the first shot gets you at about 60% effectiveness and the second brings you up to the 90+%. I've also read that you are not at any effectiveness level at all until the second shot. Which is it?
The part in red is absolutely not true of either Moderna's or Pfizer's vaccines. IIRC, each differs in the effectiveness of just one shot alone ... I really want to look it up and not post off the cuff. I do remember that both were over 50% effective at preventing infection at one dose -- which, recall, was the initial goal and is considered an effective vaccine.I've read conflicting reports on the first of two vaccine shots? I read somewhere that the first shot gets you at about 60% effectiveness and the second brings you up to the 90+%. I've also read that you are not at any effectiveness level at all until the second shot. Which is it?
52% efficacy for Pfizer and 80% for Moderna (sourced here) after one doseI've read conflicting reports on the first of two vaccine shots? I read somewhere that the first shot gets you at about 60% effectiveness and the second brings you up to the 90+%. I've also read that you are not at any effectiveness level at all until the second shot. Which is it?
Another source for the same figures and some details about other countries' vaccines here:52% efficacy for Pfizer and 80% for Moderna (sourced here) after one dose
According to Pfizer data published in December 2020, the Pfizer-BioNTech vaccine is roughly 52% effective after the first dose ...
For the Oxford-AstraZeneca vaccine, things are a bit different. In a paper published in January, the authors explain that the vaccine offers protection of 64.1% after at least one standard dose. This compares to 70.4% if you've had two full doses, or – oddly – 90% in people who have had one half dose followed by one full dose ...
According to a document the company submitted to the FDA, the Moderna vaccine can provide 80.2% protection after one dose ...
I didn't do a ton of actual research. I just know of 2 or 3 of them that were "in the works". I think Turkey has a "nasal vaccine" allegedlyAh ... this one sounds less than legitimate:
That could be legit -- a nasal influenza vaccine has been available in the Unites States since 2017 (CDC.gov).I didn't do a ton of actual research. I just know of 2 or 3 of them that were "in the works". I think Turkey has a "nasal vaccine" allegedly
The CDC ACIP (Advisory Committee on Immunization Practices) had an emergency meeting today.
The purpose of this meeting is to update everyone on the current affairs related to COVID19 vaccinations. There were a lot of big wigs in attendance: new CDC Director, FDA, NIH, DOD, HHS, CDC, AAP, ACOG, AMA, CSTE, AAP (just to name a few).
Here are your cliff notes…
• Enrollment ended in the US. 32,459 people enrolled. As of Jan 21, 26,327 trial participants have received their second dose. 57.8% have a comorbidity and 23.6% are 65+ years old. Trial participants are only getting the standard dose (not the half dose that some in the UK received)
COVID19 epidemiology among kids…
• Kids with the most severe COVID19 are in these groups (and in this order): Obesity; Asthma; Immunocompromised; Chronic lung disease; Cardiovascular disease; sickle cell disease; diabetes; cerebral palsy; down syndrome; hypertension, and renal disease.
• 1,659 cases of MIS-C in 47 states, leading to 26 deaths
Vaccines for children…
• Rationale for pediatric clinical trials: 1) Pediatric burden of disease is significant 2) Disproportionate burden among children in minority communities 3) Indirect effects to the child and society (school, development, etc.) 4) Continued burden if we wait for natural “herd” effects 5) Data suggests that vaccination prevents asymptomatic carriage, thus reversing pandemic more rapidly 6) Safety data are best collected in clinical trials
• Age de-escalation trials will be organized as the following: 6 to <12 years; then 2 to < 6 years; and infants to < 2 years
• True placebos (like saline) are being considered. Another vaccine hasn’t been proposed as a control yet
• Will test multiple dose levels (full, half, and quarter doses)
• Safety of COVID-19 vaccines are reassuring and consistent with clinical trials
• We (the U.S.) are actively collecting safety data from three main sources: V-safe (active surveillance), VAERS (passive surveillance), and Clinical Immunization Safety Assessment Project (CISA) (which investigates individual cases).
• V-safe data has been initially analyzed. 2.08M people have participated in V-safe (out of 21.8M people vaccinated). There are 15,131 pregnancies reported to v-safe (they will follow these women that consent up to 3 months after babies are born)
• See the Figure for the reactions to the vaccines being seen in real-time.
• Anaphylaxis: 50 people reported for Pfizer (out of 9.943M doses) and 21 reported in Moderna (out of 7.581M doses). 90% happened within 30 minutes of vaccination. 80% (Pfizer) and 86% (Moderna) of people had a history of allergies
• VAERS has 196 deaths reported following vaccination. None of them have been causally linked to vaccinations.
Other random notes…
• Prior COVID infection and vaccine side effects: they are designing a study to get a better idea of what’s happening
• Vaccine and transmission: This is a priority. 5,000 healthcare providers and first responders are being assessed for transmission after vaccination. They are getting tested weekly for infection.
• Among 65+ years, 90% of vaccine recipients are White. Speed is compromising health equity
• There is no additional data for delayed doses. The current recommendation remains: don't delay your second dose more than 6 weeks (42 days) after your first dose
• mRNA vaccines are NOT interchangeable unless in an exceptional situation
I've been really fascinated with seeing how it affects people. Particularly people who have had an infection vs those who (at least knowingly) haven't. Has your wife had COVID?Worrierqueen just got her first shot, Pfizer. Reports some burning on her left (injection) side and a mild headache 30 minutes after.
I'm actually jealous!
We don't think so, although we both got very sick last February. I spent Super Bowl Sunday with a 102 fever and she had fever and a cough that lasted almost two weeks. It could have been COVID but we don't know.I've been really fascinated with seeing how it affects people. Particularly people who have had an infection vs those who (at least knowingly) haven't. Has your wife had COVID?
People have asked about this a dozen times in this thread, maybe more. Thanks for posting this bit. Going to try to find a link for it (I understand you read it on Facebook).5) Data suggests that vaccination prevents asymptomatic carriage, thus reversing pandemic more rapidly
Moderna had a group of single dose.The true first dose effectiveness is really hard to gage because it’s mainly been studied in people who ended up getting both doses. For the Pfizer that’s only 3 weeks in between and even less when you consider the time each dose takes to be effective. The data being used to find the percentage is based on that small window vs infections in the placebo group. Unless there is a long term study of people who only got 1 dose, I wouldn’t put much significance on the current estimated 1st dose %.
Yeah I hate linking to FB. She has a website/blog, but it's not on there yet. I think it was just her notes from watching the meeting, as there were presentation slides as well.People have asked about this a dozen times in this thread, maybe more. Thanks for posting this bit. Going to try to find a link for it (I understand you read it on Facebook).
found it:Since it was a CDC meeting, those slides may be made public soon.
Yep, and some Harvard folks, too. Pretty early on ... some back in April. Would love to know if any of them have contracted COVID since.Didnt a bunch of MIT people give themselves their own home brew nasal vaccine a while back?
Mucosal immunity? Had no idea that was a thing ... I knew about the nasal flu vaccine, but I thought the contents of the spray made their way into the bloodstream. I wonder if instead the nasal flu vaccine works by imparting mucosal immunity?A nasal vaccine is easier to administer than one which must be injected and, in Church’s opinion, is an overlooked option in the covid-19 vaccine race. He says only five out of about 199 covid vaccines listed as in development use nasal delivery, even though some researchers think it’s the best approach.
A vaccine delivered into the nose could create what’s called mucosal immunity, or immune cells present in the tissues of the airway. Such local immunity may be an important defense against SARS-CoV-2. But unlike antibodies that appear in the blood, where they are easily detected, signs of mucosal immunity might require a biopsy to identify.
George Siber, the former head of vaccines at Wyeth, says he told Estep that short, simple peptides often don’t lead to much of an immune response. Moreover, Siber says, he doesn’t know of any subunit vaccine delivered nasally, and he questions whether it would be potent enough to have any effect.
When Estep reached out to him earlier this year, Siber also wanted to know if the team had considered a dangerous side effect, called enhancement, in which a vaccine can actually worsen the disease. “It’s not the best idea—especially in this case, you could make things worse,” Siber says of the effort. “You really need to know what you are doing here.”
He isn’t the only skeptic. Arthur Caplan, a bioethicist at New York University Langone Medical Center, who saw the white paper, pans Radvac as “off-the-charts loony.” In an email, Caplan says he sees “no leeway” for self-experimentation given the importance of quality control with vaccines. Instead, he thinks there is a high “potential for harm” and “ill-founded enthusiasm.”
Church disagrees, saying the vaccine’s simple formulation means it’s probably safe. “I think the bigger risk is that it is ineffective,” he says.
So far, the group can’t say if their vaccine works or not. They haven’t published results showing that the vaccine leads to antibodies against the virus, which is a basic requirement for being taken seriously in the vaccine race. Church says some of those studies are now underway in his Harvard laboratory, and Estep is hoping mainstream immunologists will assist the group. “It’s a little bit complicated, and we are not ready to report it,” Estep says of the immune responses seen so far.
Baxter also adds that the total deaths in Southeast Asian countries like Thailand, Laos, and Vietnam are particularly low. “Yes, they wear masks, and yes, they bow and don’t shake hands, but the biggest difference between them and places like South Korea or Japan is that nasal irrigation is practiced by 80 percent of people,” she says.Also didnt people think early on that the reason thailand or some other place had low rate of spread was because of the saline they use in neti pots?
80 percent of the people? Is that right? Huh.Baxter also adds that the total deaths in Southeast Asian countries like Thailand, Laos, and Vietnam are particularly low. “Yes, they wear masks, and yes, they bow and don’t shake hands, but the biggest difference between them and places like South Korea or Japan is that nasal irrigation is practiced by 80 percent of people,” she says.
I had this also both times. Even a little discomfort in my left wrist/forearm when lifting weights that I didn't initially tie in.I'm three days in on mine after the first shot and so far it's been fine other than some arm soreness the first night about 6-8 hours after the shot. I'll update if anything changes, although one of the nurses I spoke to when getting the shot said her armpit lymph nodes became sore about a week after the first shot. She also said that one or two other nurses who got their shot at the same time reported this as well.
I meant to edit, but whatever.I'm 34 hours in on shot number one, 2PM Tuesday 1/26. I believe I had covid just before Christmas to a little after New Year's. I've had arm soreness from the onset, starting the next morning a minor chronic injury has been acute and now I've got the chills.
It’s probably based on a neutralization titer of vaccinated individuals’ serum inoculated with SARS-CoV-2 strain(s) with the mutation(s) of interest, in comparison to regular (wild type) virus. Sixfold reduction means serum retains its neutralizing ability (detailed below for an influenza microneutralization assay) after diluting to 1/6 the concentration for the wild type virus versus the mutant being studied. If vaccines generate antibodies effectively enough, a several fold reduction in their potency won’t necessarily result in a meaningful change in clinical efficacy.The article linked doesn't answer this squarely: What, exactly, does a "sixfold reduction" mean here? From ~95% effective to ~16% effective? 1/6 the number of antibodies per unit of blood? Something else? The article says exactly this:
The microneutralization test is a highly sensitive and specific assay for identifying influenza virus-specific, neutralizing antibodies in animal and human sera (9). The 2-day assay is performed in two stages. On day 1 of the assay (1) a virus-antibody reaction step, in which virus is mixed with dilutions of serum and time allowed for antibodies to react and (2) an inoculation step, in which the virus-serum mixture is inoculated into the appropriate host system, MDCK cells in this assay. An ELISA is performed on day 2 of the assay to detect virus-infected cells. The absence of infectivity constitutes a positive neutralization reaction and indicates the presence of virus-specific antibodies in the serum sample. The preferred serum samples in cases of influenza-like illness are paired acute and convalescent serum samples with the acute collected less than 7 days after symptom onset and the convalescent collected at least 14 days after the acute sample and ideally within 2-3 months of illness onset. A fourfold or greater rise in antibody titer demonstrates a seroconversion and is considered to be diagnostic. With single serum samples, care must be taken in interpreting low titers such as 20 and 40. Generally, knowledge of the antibody titers in an age-matched control population is needed to determine a minimum titer that is indicative of a specific antibody response to the virus utilized in the assay.
per CDC website:How soon should I push a second shot if one becomes available? 3 weeks like Pfizer? 3 1/2 weeks?
I guess you didn't get tested?I'm 34 hours in on shot number one, 2PM Tuesday 1/26. I believe I had covid just before Christmas to a little after New Year's. I've had injection site soreness from the onset, starting the next morning a minor chronic injury has been acute and now I've got the chills.
I had two negative PCR (15 minute) tests. I was diagnosed with an upper respiratory infection but now think it was a misdiagnosis. I had a blood draw for an antibody test, at the same time as my second PCR and diagnosis, that came up positive. My symptoms were more aligned with a covid infection. I first had fatigue, then shortness of breath, body aches and kidney pain. I never had a cough, fever or any loss of taste or smell.I guess you didn't get tested?
Doesn't the CDC recommend not getting the vaccine until 3 months after having the virus or is that just due to supply?