Give me Kansas. 4 legit NBA players and a solid, experienced PG. Assuming Embiid is healthy, too many options offensively between Selden, Ellis, Wiggins, Embiid to go cold and their defense should be good enough.
They did lose SU to Florida. Didn't catch that game so maybe I'll try to watch that since I'm not well versed on Florida.
Teams that can play 3/4 or full court pressure defense, especially pressure on the PG, will give Kansas trouble. Florida opened up a big lead on Kansas running a 3/4 court trap that produced a lot of turnovers 30-40 feet from basket. Villanova did the same thing when they beat KU at Atlantis. The PG situation is average for D-I, subpar for a power conference leader. Selden is a good enough passer to help break presses from SG and Ellis can come up from PF to be a midcourt target against zone traps. Wiggins is great at attacking the basket after the press has been broken from SF, but he's not a good enough dribbler with his off-hand to help break good presses.Overall, PG is KU's weak link. Starting PG Naadir Tharpe has improved in halfcourt offense, but he struggles with pressure D and goes for the SportsCenter pass too often on transition. Back PG Frank Mason can break down his man and get in the lane from out top, but is slow to recognize double-teams.
Self will sometimes play both PGs together to speed the game up. Tharpe is a good enough shooter to play college SG, and is a much better defender in space than on the ball. They also have a 3rd PG option against zone defense in combo guard Connor Frankamp, but his handle isn't tight enough to reset a broken play against man D.
On the strengths side... Lots of depth down low and lots of speed on the perimeter. Backup bigs Tarik Black and Jamari Traylor would start for most power conference teams, but they are 10-15 minute players unless Embiid is hurt or in foul trouble. Selden doesn't look fast at first but he's so smooth he's making it look easy. Wiggins will lull his man to sleep and then go into Blur Mode to draw foul and/or get to the rim. Backup SF Brannen Greene is already an NBA-caliber shooter with NBA wing height and length, but lack of defensive fundamentals on the court and bad decisions off it have limited his playing time. For all his weaknesses, Tharpe has good speed for his position, and Mason has an uncommon breakaway gear with the ball for going coast-to-coast.
There's enough offensive balance to avoid long slumps and to battle through foul trouble, but Greene and Frankamp are the only two guys on the roster capable of shooting 6-for-8 or 7-for-9 on three-pointers, and neither are good enough defensively to play long stretches for Self. Self will forgive a bad shot if you get back on D and stop your man, but he has little patience for defensive lapses.
The teams to look for to knock KU out in the tourney are teams that create a lot of turnovers on defense and makes threes in volume from different sources on offense. The teams that played KU close did have done one of those well, and teams that beat them did both.
Also keep an eye on Embiid's health. He hasn't been 100% since conference play started and he's missed some games and practices. For a guy still learning the game like Embiid is, a missed practice carries more loss than most future lottery picks.