An injury can happen to anyone at any time, however, the more times you get hit, the more likely you are to get injured. With that said, my order would look like this, in order of most likely.Marion Barber - The Cowboys will probably limit his touches for this very reason, but the guys break so many tackles, he seems to get hit two, three times every time he touches the ball.Marshawn Lynch - As a Bills fan, i am glad to see Fred Jackson come on last year to be a nice change of pace back. Like Barber, Lynch runs extremely hard and seems to get hit multiple times on every carry.Frank Gore - Has a bit of injury history, and as the only real offensive weapon, the 49ers will probbly use him early and often. He doesnt seem to get involved in as many violent collisions the previous two RB's do, but he will take his fair share of hits just on the amount of touches he gets.Clinton Portis - Like Gore, he doesnt really seek out contact, but unlike Gore, the Skins have other weapons, and wont have to rely so much on him.Barber is the only one who really scares me when it comes to injury. I dont think he gets near 300 touches without getting hurt.