It depends on your league's scoring. Johnson, Peterson, Lynch, Jarrett, and Ginn are the elite offensive prospects. After those guys, a lot will depend on which second tier RBs are drafted when and by whom. All we can do right now is guess. In a PPR, I'd say it will go something like this:
1. Adrian Peterson - Name recognition should keep him at #1, even if he's not really the best prospect available.
2. Marshawn Lynch - Solid. Could easily go before Peterson when all is said and done, and could be a better pro.
3. Calvin Johnson - Best player in the draft. Should be the #1 pick in PPR, but teams at the top usually need RBs.
4. Dwayne Jarrett - Underrated all along. Not as good as Johnson, but still projects as a #1 WR.
5. Kenny Irons - Every year a couple second tier RBs move up into the top 6 picks. Irons should be a top 90 pick in the NFL draft.
6. Ted Ginn - One of the true boom-or-bust picks in this class. Ginn could either be a complete star or a complete flop. He'll go early in the NFL draft, which means someone in your league will roll the dice.
7. Brady Quinn - This is about where the QB1 tends to go. There are lots of Notre Dame fans out there, which means Quinn could go earlier than expected in some leagues.
8. Lorenzo Booker - Booker will be a 2nd-3rd round pick come April and is a good sleeper. Could wind up going higher than this in rookie drafts if he lands in a favorable situation.
9. Tony Hunt - Don't know much about him, but RBs are always in demand.
10. Jamarcus Russell - Top high school prospect will be a first round NFL pick.
11. Jeff Samardzija - Could go in the first round. I don't like him, but someone might take a chance.
12. Michael Bush - I don't see any reason to believe he'll do any better than Eric Shelton, but that doesn't mean an NFL team won't pick him.
Names to watch:
Robert Meachem, WR, Tennessee
Jason Hill, WR, Washington State
Sidney Rice, WR, South Carolina
Dwayne Bowe, WR, LSU
Craig Davis, WR, LSU
Dwayne Wright, RB, Fresno State
Tyrone Moss, RB, Miami
Gary Russell, RB, Minnesota
Greg Olsen, TE, Miami