My initial reaction is that of course I'd want as much info as possible before guessing The worst I can imagine is that X is irrelevant, in which case there's still no real harm in knowing it. Due to the nature of the question, though, I assume you have some reason why I shouldn't want to know X? I'll have to give it some thought.
If you wanted that information, how would you use it?

Honestly, off the top of my head I'd have no idea what a reasonable guess would be for the average number of interceptions, whether I know X or not. I'm not saying I would definitely benefit from knowing X, but I still don't see how it would be
bad to have that information. So I'd take it, and then decide if it was useful.
I think maybe you're trying to make the point that X is irrelevant, which is interesting if true, but that wouldn't mean I still wouldn't ask for the information anyway. The only reason I'd prefer not to have the information is if it's somehow "bad" to know it (i.e. knowing it would reduce my chances of guessing correctly) but I'm having a hard time imagining how that would be the case.
Probably a stupid clarification, but is an interception counted as an incomplete pass? In other words, is their total number of interceptions included in the 12 incompletions they threw, or is it really 12 + interceptions + completions = X?
An interception is counted as an incompletion, yes.FWIW, the avg QB threw 2.9 interceptions per 100 pass attempts last year.
Think of it this way:
I told you he threw 20 passes. What is your answer?
I told you he threw 50 passes. What is your answer?

Let's say my answer is 1.2 either way. Average QB threw 3 per 100 attempts last year. So this would lead you to believe that on 20 attempts, the average QB would throw 0.6 INTs. But a guy who goes 8/20 has presumably done worse than average, so you'd adjust that estimate upwards.
You'd also believe that on 50 attempts, the average QB would throw about 1.5 INTs. But a guy who goes 38/50 has presumably done better than average, so you'd adjust that estimate downwards.
The problem is, if you hadn't told me, I'd have no idea how many INTs/attempt the average QB threw last year. That's really the useful information that would help me make a better guess, not X.
So I'm still reaching the conclusion that your point is that the number of attempts is irrelevant, all you need to know is the number of incompletions. If true, I think that's a fun and interesting point. I just think you posed it in a weird way in the OP. Unless I seriously cared about "not wasting my breath with irrelevant questions" I still think it does no harm to ask for X. I might ultimately determine that X is irrelevant, but I'd still want to know it before guessing.