OK.. so its pretty hard to determine if something is truly random. Its fairly easy to prove something is NOT random because you only need one example of when its not random. Once its not random, you can throw those stats out the window.
There seems to be 2 camps, the 1:144 camp and the 1:12 camp.
Lets look at the 144 camp first. They're assuming to random events occur with 1:12 frequency. The first is total points, the second is total points against.
Lets assume PPR league scoring
Team A:
QB Aaron Rodgers
RB Adrian Peterson
RB LeSean McCoy
WR Reggie Wayne
WR Andre Johnson
WR Calvin Johnson
TE Antonio Gates
Team B:
QB Tyler Thigpen
RB Shonn Green
RB Ryan Mathews
WR Jordy Nelson
WR Brandon Tate
WR Devin Hester
TE Jeremy Shockey
These teams both have a 1-12 chance of being total pts leader because everything in fantasy football is random? Of course not... so the 1 in 144 example is wrong because the first event doesn't have a frequency of 1-12. I don't know whats right, I'm just pretty sure that 1:144 is wrong.
Lets look at the 1:12 camp
Now, you have a 12 team league with 3 divisions, 13 week schedule. You play everyone in you division twice (6 games) and 7 of the remaining 8 teams. So you have unbalanced schedules, you don't have an equal chance of all outcomes. For example, Team A might not play the highest scoring team at all, while team B plays them twice.
Thats not random (that schedule isnt even random).
Lets look at in on the player level. Right now Aaron Rodgers is one of the highest scoring players in many formats. Its possible that Rodgers can get traded mid-season in a fantasy league and up playing one team A 3 or 4 times and never play against team B.
Do you see what I'm getting at? "Unpredictable" and "random" are two different things...