I am certainly the noob and am open to any and all suggestions.
The reasons I had for 1st day was we were told by others that had traveled to Europe that doing something active to stay moving and awake would be the best way to get over the jet lag. Push through, go to bed at a decent time, and wake up ready to go the next day. I figured Duomo would fit the bill. I had looked at all of the times open and it seemed to work out. Still, I had originally thought just wander that day. We are staying in a room from AirBnB so we can drop off our bags anytime. I put Uffizi and Academia Sunday because I wanted to leave Saturday wide open for some kind of Tuscan tour. I sent a request to Sergio, will hear back in 48 hours he says.
As for the Sorrento, Pompeii, etc. Pompeii is a very short train ride from Sorrento, where our room is. I figured it would make sense, but I guess it depends how long you all would suggest I spend in Pompeii. I have heard it is easily all day, others say 2-3 hours. If only 2-3 hours, we would be able to give another day to Amalfi area and hit it on the way up to Rome, but then we would also have our luggage. Thoughts here are welcome.