Okay, so this home/away QB comparison is intriguing to me. Let's investigate...
As it relates to this thread, let's compare Brees's 4 games on the road this year to Wilson's 5 games at home. (Rankings will exculde non-QBs with passing attempts)
Completions
Brees (road): 102/168, 25.5/game (#7) 60.7% (#14)
Wilson (home): 77/115, 15.4/game (#40), 67.5% (#7)
Net passing yards per game
Brees (road): 293.7/game (#5), 7.3/attempt (#17)
Wilson (home): 201.0/game (#27), 8.75/attempt (#3)
Touchdowns
Brees (road): 7 (#13), 1.75/game (#9), 0.042/attempt (#21)
Wilson (home): 9 (#7), 1.8/game (#13), 0.08/attempt (#4)
Interceptions
Brees (road): 5, 1.25/game, 0.030/attempt
Wilson (home): 4, 0.8/game, 0.035/attempt
So Brees throws a lot more, about 10 more completions per road game than Wilson per home game, but is 6.8% less accurate.
Interestingly, Wilson has still thrown more touchdowns per game at home than Brees on the road, and Brees throws 0.95 more interceptions per road game than Wilson at home. I guess we can make a stat for that, (though I'm certain one probably exists). TD/game : INT/game, let's call it TI/g:
Brees (road) TI/g: 1.4
Wilson (home) TI/g: 2.25
Of course the modifier for how the passing game functions here is the defense, so let's look at some Seahawks home passing defense vs. Saints road passing defense numbers.
Completion percentage
New Orleans D (road): 16.8/29.5 56.78 (#2)
Seattle D (home): 16.8/30.8 54.55% (#3)
Pass yards per game, Pass yards per attempt
New Orleans D (road): 207ypg (#5), 7.0ypa (#16)
Seattle D (home): 165.4ypg (#2), 5.4ypa (#2)
Pass TD/INT per game
New Orleans D (road): 1.0 (#3) / 0.5 (#26)
Seattle D (home): 1.0 (#8) / 2.0 (#1)
Passer Rating
New Orleans D (road): 85.1 (#10)
Seattle D (home): 55.9 (#1)
So it looks like the devil is in the details. You don't have to throw against New Orleans Defense when they are on the road much to be efficient. They give up considerably more yards per attempt than their yards per game suggests, and Wilson is #3 in the league for yards per attempt at home, suggesting this is a much better matchup for him than people think. Additionally, they haven't been good at intercepting the ball, and Wilson rarely throws them at home anyway. Brees throws a lot of passes, which is ideal for Seattle's propensity for intercepting the ball, especially at home. Seattle has been so much better than the rest of the NFL at intercepting the ball at home, their interception per attempt percentage of 6.49% is a full 37% higher than the next best team (#2 Chicago, 4.74%). Only 2 teams in the last 10 seasons (as far back as I can see) have been that good. For comparison, on the road, New Orleans intercepts just 1.69% of passes attempted, the 8th worst in the league.
On paper, this passing matchup looks to favor the Seahawks much more than anyone will be bold enough to recognize. Where Wilson is strong (yards, TDs, INTs per attempt), New Orleans' defense has been vulnerable on the road. Where Brees appears to be strong (sustained passing attack) is precisely where the Seahawks D has appeared to feast at home. The sample size may still be too small, but New Orleans will need to play better against the Seahawks on the road than they have played against the teams they've faced outside of New Orleans thus far to overturn what that sample foretells.
(ETA: number of games played)