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*** OFFICIAL *** COVID-19 CoronaVirus Thread. Fresh epidemic fears as child pneumonia cases surge in Europe after China outbreak. NOW in USA (14 Viewers)

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Everything you brought up is a solvable problem. Solving such problems is a matter of will.

What's the hang-up on getting Americans food in a hypothetical hard lockdown situation? There are a jillion other ways to do that besides "work for wages, then go buy food".

And heck -- even in Wuhan during the hardest part of their lockdown ... households were allowed to grocery-shop weekly.
The people in NYC set up a free service to get high-risk (elderly) people groceries and other goods. It even extended to other cities. Free. Because people (even the young ones that keep getting dumped on for going to bars/parties) can actually be awesome. We simply have have to choose to be. 

Another brutally bad argument. I don't know how you have the patience to continue addressing them, honestly. You and @Terminalxylem have shown such incredible character in here. Thank you both (and many others) for continuing to stay the course. 

 
Flying Elvis said:
The people in NYC set up a free service to get high-risk (elderly) people groceries and other goods. It even extended to other cities. Free. Because people (even the young ones that keep getting dumped on for going to bars/parties) can actually be awesome. We simply have have to choose to be. 

Another brutally bad argument. I don't know how you have the patience to continue addressing them, honestly.
We're not simply addressing the people posting in this thread ... we're also addressing a good number of readers who don't post in the thread. Not everyone that participates in a thread like this will be swayed by the posts of those who debate against them -- but there are people on the sidelines worth reaching.

 
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Why some people who haven't had Covid-19 might already have some immunity

"The immune systems of some people who have not been exposed to the novel coronavirus could have some familiarity with the pathogen -- possibly helping to reduce the severity of illness if that person does get Covid-19, a new study suggests.

The study, published in the journal Nature on Wednesday, found that among a sample of 68 healthy adults in Germany who had not been exposed to the coronavirus, 35% had T cells in their blood that were reactive to the virus.

It's not entirely surprising because these are all members of a family. It's as though they're cousins in the same family," he said. "Now we have to see whether there is any impact of this in clinical practice. ... Does it make it more or less likely that the person who is infected with Covid actually will develop an illness? And does it have any implications for vaccine development?"
My friend who is a pediatric infectious disease doctor speculated months ago that this was a possible reason for kids having a much better results since kids pick up colds so easily and basically constantly have them most kids have been exposed to the simple cold Coronavirus recently so have a better immune response.  I haven't talked about this topic with her in awhile but can ask her about it again next time I talk with her.   

 
My friend who is a pediatric infectious disease doctor speculated months ago that this was a possible reason for kids having a much better results since kids pick up colds so easily and basically constantly have them most kids have been exposed to the simple cold Coronavirus recently so have a better immune response.  I haven't talked about this topic with her in awhile but can ask her about it again next time I talk with her.   
Ask what she thinks of theories regarding angiotensin-converting enzyme 2 (ACE2) expression in children, as well. This seemed to be a hotter topic two months ago, but I wonder if researchers weren't kind of on the right trail. The NIH article below (the second one) does hypothesize a multifactorial set of causes for mildness of COVID-19 in children: trained immunity like your friend mentioned, lymphocyte count, and ACE2 expression. There's also consideration of just where in the respiratory tract the ACE2 is getting expressed ('nasal and sinus tissue' vs. 'the lungs, esp. the alveoli themselves') and how that effects severity of COVID-19 infection.

Doubtlessly, the science here is not yet pinned down and few conclusions have achieved consensus. Still, there's plenty to read -- and think -- about.
 

Less Nasal ACE2 May Explain Fewer COVID-19 Cases in Children (Contagion, 5/28/2020)

A new study found that children have less angiotensin-converting enzyme 2 (ACE2) in nasal epithelium than older populations, which might confer some protection against SARS-CoV-2 entering cells at this vulnerable site for infection and transmission, and explain their lower incidence of coronavirus 2019 (COVID-19).


Will children reveal their secret? The coronavirus dilemma (NIH.gov, 4/2/2020)

Epidemiological evidences show that SARS-CoV-2 infection in children is less frequent and severe than adults. Age-related ACE2 receptor expression, lymphocyte count and trained immunity might be the keystone to reveal children's secret.


Why COVID-19 may be less common in children than adults (Science Daily, 5/22/2020)
Findings could lead to potential biomarker of susceptibility

The virus that causes COVID-19 uses a receptor known as ACE2, found on the surface of certain cells in the human body, to enter its victims. Now, Mount Sinai researchers have found that children have lower levels of ACE2 gene expression than adults, which may explain children's lower risk of COVID-19 infection and mortality. Gene expression is a measure of how much a gene is transcribed.

These results, published in JAMA on Wednesday, May 20, may point to a potential biomarker of susceptibility to the virus, known as SARS-CoV-2.
And here, an excerpt from a more recent article published by National Geographic which does a good job synthesizing recent research for the layman:

from  Here's what COVID-19 does to a child's body (National Geographic, 7/24/2020):

One prevailing theory for children under 10 don’t seem to get as sick has to do with an enzyme called ACE2. When SARS-CoV-2 enters the body, the spikey proteins encircling the virus latch on to ACE2 like a key fitting into a lock.

“One of the theories is that children have the [ACE2] receptors for this virus more in the nose [and] in the upper respiratory system than in the lungs, and adults have these receptors in the lungs,” says Elizabeth Barnett, chief of pediatric infectious diseases at Boston Medical Center and professor of pediatrics at Boston University School of Medicine.

Producing more ACE2 receptors in the lungs is one theory for why adults have more serious COVID-19 infections, she notes.

One study of 305 people from four to 60 years old found that ACE2 enzymes were least active in children under 10.

More resilient and adaptive immune systems may also help young children fend off the disease, says Alvaro Moreira, a neonatologist at the University of Texas Health Science Center in San Antonio. He describes two methods of attack used by a person’s immune system: “one that doesn’t require memory and one that does.”

Over time, as we age and get exposed to bacteria and viruses, our bodies' immune systems create cells that remember specific viruses and can later attack them more efficiently. A child’s body that’s still building this memory relies on the immune system’s other method of attack.

“That’s the innate immune system,” says Moreira. “And we know children are less likely to mount an exaggerated innate response.”

When the innate immune system attacks, immune cells indiscriminately take on pathogens that enter the body. It’s also during this onslaught that the body releases molecules called cytokines, which help cells communicate with one another. When the immune system unleashes too many cytokines, they attack healthy tissue. Some of the sickest adult COVID-19 patients have died from these so called “cytokine storms.”

Kids tend to have lower cytokine levels to protect them from such storms, says Tschudy, possibly because, “young children are exposed to new infections all the time, so when their bodies are exposed to a new virus like COVID-19, their immune systems may be primed to respond just strong enough to fight the virus and not cause their bodies harm."

 
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Ask what she thinks of theories regarding angiotensin-converting enzyme 2 (ACE2) expression in children, as well. This seemed to be a hotter topic two months ago, but I wonder if researchers weren't kind of on the right trail. The NIH article below (the second one) does hypothesize a multifactorial set of causes for mildness of COVID-19 in children: trained immunity like your friend mentioned, lymphocyte count, and ACE2 expression. There's also consideration of just where in the respiratory tract the ACE2 is getting expressed ('nasal and sinus tissue' vs. 'the lungs, esp. the alveoli themselves') and how that effects severity of COVID-19 expression.

Doubtlessly, the science here is not yet pinned down and few conclusions have achieved consensus. Still, there's plenty to read -- and think -- about.
 

And here, an excerpt from a more recent article published by National Geographic which does a good job synthesizing recent research for the layman:
Thanks for this info! Does anyone have insight into whether this suggests ACE inhibitors like Captopril and Lisinopril might be effective in quelling cytokine storms?

 
Hard not to steer political when your leader says we have so many cases because we test too much...sorry moderators, but thats a huge load of hot HS that needs to be denounced from every sane person.

meanwhile, my test came back negative so back to work for me. My wife wont get hers until Monday but believe she's far more likely negative as well. All these headaches must be stress + allergies being inside around her dogs and cats more 

 
Hard not to steer political when your leader says we have so many cases because we test too much...sorry moderators, but thats a huge load of hot HS that needs to be denounced from every sane person.

meanwhile, my test came back negative so back to work for me. My wife wont get hers until Monday but believe she's far more likely negative as well. All these headaches must be stress + allergies being inside around her dogs and cats more 
My allergies have been killing me for weeks and I NEVER get allergies in the summer. I have woken up many nights with sudden allergy attacks. Its bizarre. Yes I know they are allergies because they stop when I take Allegra. I have a theory that they are bothering me so much this summer because during my normal bad allergy season (April/May) I barely left the house.

 
Does anyone have insight into whether this suggests ACE inhibitors like Captopril and Lisinopril might be effective in quelling cytokine storms?
Though this is from Wikipedia, the information below is pretty recent (excepting info from an April study in Hubei, China). All this information is annotated and linked for anyone that wants to dig deeper (annotated links included below).

Both ACE inhibitors and angiotensin II receptor blockers (ARBs) that are used to treat high blood pressure have been shown in rodent studies to upregulate ACE2 expression hence may affect the severity of coronavirus infections.[36][37] A systematic review and meta-analysis published on July 11, 2012, found that "use of ACE inhibitors was associated with a significant 34% reduction in risk of pneumonia compared with controls." Moreover, "the risk of pneumonia was also reduced in patients treated with ACE inhibitors who were at higher risk of pneumonia, in particular those with stroke and heart failure. Use of ACE inhibitors was also associated with a reduction in pneumonia related mortality, although the results were less robust than for overall risk of pneumonia."[38] An April 2020 study of patients hospitalized in Hubei Province in China found a death rate of 3.7% for hospitalized patients who had hypertension and were on ACE inhibitors or ARBs versus 9.8% for hospitalized patients with hypertension not on such drugs, suggesting that the drugs are not harmful and may help against the coronavirus.[39]

Despite lack of conclusive evidence, some have advocated for and others for the cessation of ACE inhibitor or ARB treatment in COVID-19 patients with hypertension.[40] However, multiple professional societies and regulatory bodies have recommended continuing standard ACE inhibitor and ARB therapy.[41][42][43]

 
My allergies have been killing me for weeks and I NEVER get allergies in the summer. I have woken up many nights with sudden allergy attacks. Its bizarre. Yes I know they are allergies because they stop when I take Allegra. I have a theory that they are bothering me so much this summer because during my normal bad allergy season (April/May) I barely left the house.
Been a bad year for me illness wise. Had the worst cold of my life in January that laid me out for a week, then another a couple months later. Worst allergies in years too, though like I said before I suspect that's from too much time indoors. I'm mildly allergic to cats and dogs and my daughter moved home in December with 3 of them to add to 3, then all this social isolation means more time at home

 
Haven't read the whole thing yet ... but the CDC has published a report about a COVID-19 outbreak at an overnight youth camp in Georgia. Here are the Cliffs Notes, from Nature and National Geographic contributor Amy Maxmen's Twitter:

NEW from CDC: #COVID19 outbreak at an overnight camp in Georgia infects *at least* 260 campers & staff.
   -51% of positives 6-10yo
   -44% 11-17 yo
   -Camp required a test <12 days before arriving & attempted "pods"
   -Masks required for staff but NOT campers
   -*Out of 597 campers & staff, 344 were tested and 76% of those tests were positive
   -26% positives report no symptoms
   -Bottom line from @CDCgov: Children of *all* ages are susceptible to #SARSCOV2 & "might play an important role in transmission"



 
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Just  kicking around some potential COVID-19-Inspired band names.  Got to keep practicing the guitar in case any of these catch on:

Cytokine Storm

The New Normal

The Super Spreaders

Elon Mask

Sputum (Punk Band)

Herd Immunity

Bats and Pangolins

The Second Wave

Worldometer

The Quaran-Teens (Boy Band)

Aerosol Transmission

Contact Tracers

The Fomites

Lagging Indicators

Co-Morbidities

Nasal Swabs

Just the Flu

Patient Zero

The False Positives

Viral Load

The Karens

 
Just  kicking around some potential COVID-19-Inspired band names.  Got to keep practicing the guitar in case any of these catch on:

Cytokine Storm

The New Normal

The Super Spreaders

Elon Mask

Sputum (Punk Band)

Herd Immunity

Bats and Pangolins

The Second Wave

Worldometer

The Quaran-Teens (Boy Band)

Aerosol Transmission

Contact Tracers

The Fomites

Lagging Indicators

Co-Morbidities

Nasal Swabs

Just the Flu

Patient Zero

The False Positives

Viral Load

The Karens
The spike proteins

 
My allergies have been killing me for weeks and I NEVER get allergies in the summer. I have woken up many nights with sudden allergy attacks. Its bizarre. Yes I know they are allergies because they stop when I take Allegra. I have a theory that they are bothering me so much this summer because during my normal bad allergy season (April/May) I barely left the house.
Same thing has been happening to me.  When I got tested last month, part of the motivation was because of my allergy symptoms and I never have allergies into July.  

 
Just  kicking around some potential COVID-19-Inspired band names.  Got to keep practicing the guitar in case any of these catch on:

Cytokine Storm

The New Normal

The Super Spreaders

Elon Mask

Sputum (Punk Band)

Herd Immunity

Bats and Pangolins

The Second Wave

Worldometer

The Quaran-Teens (Boy Band)

Aerosol Transmission

Contact Tracers

The Fomites

Lagging Indicators

Co-Morbidities

Nasal Swabs

Just the Flu

Patient Zero

The False Positives

Viral Load

The Karens
Socially Distant Flubros

 
My allergies have been killing me for weeks and I NEVER get allergies in the summer. I have woken up many nights with sudden allergy attacks. Its bizarre. Yes I know they are allergies because they stop when I take Allegra. I have a theory that they are bothering me so much this summer because during my normal bad allergy season (April/May) I barely left the house.
Stupid question but why do you stop taking Allegra? I had terrible allergies during the summer, went to an allergist, prescribed Allegra and I've taken one a day for the last 500 years, no more allergies.

 
Stupid question but why do you stop taking Allegra? I had terrible allergies during the summer, went to an allergist, prescribed Allegra and I've taken one a day for the last 500 years, no more allergies.
I used to have to do that also. Started (for a while) daily use of the Sinus Rinse (squirt bottle variety) by Neilmed. I maybe take a pill now twice a year. I do the rinse once or twice a week as needed. Highly recommend. 

 
Stupid question but why do you stop taking Allegra? I had terrible allergies during the summer, went to an allergist, prescribed Allegra and I've taken one a day for the last 500 years, no more allergies.
Because I rarely get allergies except in April/May. My son, however,  is on Allergra for 6 months now. Doc  says there's no harm.

 
Cases seem to be dropping in hospitalized COVID patients at Miami's 2 largest health systems, Jackson (449, 428, 471, 456, 472, 485, 465, 433, 421, 408 ) and Baptist (808, 785, .., ..., 746, 704, 650, 619)  https://twitter.com/jacksonhealth

County-wide numbers of hospitalized COVID patients are also trending down, although not a fast: https://twitter.com/conarck/status/1288891345575325697

In other news: How many health workers has COVID killed? Fla. says it has no data. False, ex-data guru says. Seems like Florida and Texas aren't making it easy to find out how many many nurses, etc have died with COVID-19, but California is more transparent. It took a lawsuit for Tallahassee to release data about deaths in individual nursing homes.

Perhaps reported earlier : Cases Declining, Deaths Rising, Hospital Data Remains a Question Mark: This Week in COVID-19 Data, July 30

Many of the tracking web-sites are so much better on my laptop than my phone.
The county metrics for COVID-19 hospitalizations and those at the big 2 hospitals, Jackson and Baptist, continue to trend lower. It could be a combination of partial herd immunity and cautious behavior. Deaths are lagging, so today was  high for Miami-Dade with 96 deaths reported.  Not sure if that was some type of "data dump" but there were local reports of refrigerated trailers at a funeral home in Hialeah

 
  Quote
NEW from CDC: #COVID19 outbreak at an overnight camp in Georgia infects *at least* 260 campers & staff.
   -51% of positives 6-10yo
   -44% 11-17 yo
   -Camp required a test <12 days before arriving & attempted "pods"
   -Masks required for staff but NOT campers
   -*Out of 597 campers & staff, 344 were tested and 76% of those tests were positive
   -26% positives report no symptoms
   -Bottom line from @CDCgov: Children of *all* ages are susceptible to #SARSCOV2 & "might play an important role in transmission"
Guess this should put the question about school right to bed, but I'm sure it won't

 
Covid worldometers ends the work week with little change: 282,000 new cases, US with 71,000 new cases.  6,200 deaths worldwide; US with 1,462 deaths. 

The US is now approaching 157,000 deaths. With the trend line on US deaths heading up again, with few solutions and not enough discipline in place, and the added risk of fall activities ...the US could be climbing toward a quarter million deaths by the time of the election.

 
Italian study shows a 66% decrease in death rate with Hydroxychloriquine + azithromycin.

Need a serious meta study here.  The results for HQ are all over the map, though the assertions that HQ is effective can't just be brushed away with studies like this.
Outcome studies aren't really super useful.  Difficult to control for all factors. What I understand is hcq takes 10+ days to even show in tissue and with slow testing there is hardly any opportunities for it to work even if it did anything, which seems most likely. 

 
Early run to the store this morning on Day 1 of the Wisconsin mask mandate.   No change since it won't be monitored by law enforcement.    👍

God I love this country.    

 
Just  kicking around some potential COVID-19-Inspired band names.  Got to keep practicing the guitar in case any of these catch on:

Cytokine Storm

The New Normal

The Super Spreaders

Elon Mask

Sputum (Punk Band)

Herd Immunity

Bats and Pangolins

The Second Wave

Worldometer

The Quaran-Teens (Boy Band)

Aerosol Transmission

Contact Tracers

The Fomites

Lagging Indicators

Co-Morbidities

Nasal Swabs

Just the Flu

Patient Zero

The False Positives

Viral Load

The Karens
Mötley Flü

 
Early run to the store this morning on Day 1 of the Wisconsin mask mandate.   No change since it won't be monitored by law enforcement.    👍

God I love this country.    
Puffing your chest out because you won't allow a soft piece of cloth to touch your face for half an hour.  lol.

 
They excluded patients on other drugs to take that variable out.   The p-value showed significance at the .01 level.  It's worth looking into in an unbiased way.  
Not saying it's not worth looking at.  What I'm saying is when you take out simply the drug component, you still have a correlation vs causation problem because of the 500 other variables.  I'd love for there to be an actual controlled study on these drugs then it would put this "issue" to rest and get rid of all this anecdotal nonsense.  It's pure political BS that has no business existing.

 
They are too far dug in, they can never acknowledge anything positive about it. Cause...well you know. 
And yeah...."dug in" on the scientific method that has gotten us to where we're at as a civilization.  You frame that like it's a bad thing.  Because....well you know.  Your nonsense belongs in the PSF, not here.  Are you lost?

 
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Sure - the injection of bias into this drug has been astonishing.

No worries, though, Leronlimab is the cure all we've been waiting for.   :P
Can't say I'm up on any of the specific drugs.  For instance, never heard of this one you list here.  Is that the HIV drug?  Are people claiming it's "the cure" like they are with HCQ?  Hopefully it's been through the process otherwise it's no different than HCQ as far as I'm concerned.  This isn't difficult.  Put the drugs through their paces and test.  We don't need any of this stuff to be pushed because of political agenda.  

Personally, I think people should be paying attention to how these vaccines are going and being developed more than these patchwork drugs (which is why my first sentence exists). Seems like, of the lot, that in Oxford is going about it correctly.  Can't get enough information about the vaccines being researched here in the US to have the same comfort level...shocking, I know.  It is what it is.

 
I find myself noting certain moments of "if i test positive, this will definitely be where I got it"

Anybody else? 
I picked up 5 Guys last night and they had about 15 people crammed into the tiny kitchen and every time the person spoke to me she pulled her mask down( and I immediately backed up a few feet.  So yeah, that was a moment for me.  

But ####in' A, was it worth it.  

 
Couple heartbreaking moments from the last couple days at work.

One of our favorite customers recently lost his wife after a long battle with cancer. Saw him almost daily while taking his wife was sick, less frequently now. Since his wife passed he’s been more social in the retirement community. While he’s always wearing a mask, we doubt he’s staying out of groups. Last couple times in he’s been noticeably short of breath, recently got some breathing medications and yesterday got a call from the hospital asking about his drugs specifically his history of breathing treatments. No confirmation but we’re pretty worried it’s COVID.

Then this morning another favorite customer who always shows her appreciation for us (rare in retail) told me that she hadn’t seen her husband since March. He’s in a memory home and she’s afraid when she finally can that he won’t remember her because of his Alzheimer’s.

#### this virus 

 
Can't say I'm up on any of the specific drugs.  For instance, never heard of this one you list here.  Is that the HIV drug?  Are people claiming it's "the cure" like they are with HCQ?  Hopefully it's been through the process otherwise it's no different than HCQ as far as I'm concerned.  This isn't difficult.  Put the drugs through their paces and test.  We don't need any of this stuff to be pushed because of political agenda.  
No - it's an investigational drug that may be effective in knocking down the inflammation that COVID causes.  Anecdotally it looks to be good, but the bigger studies aren't there yet.

Purely therapeutic, so not a cure.

 
I find myself noting certain moments of "if i test positive, this will definitely be where I got it"

Anybody else? 
Yes....when I was at a semi-packed bar 3 weeks ago.  Spent quite a few hours there with no masks worn by anyone.   

On a side note, had to take a trip to the gas station/convenience store about 30 minutes ago and 1 out of 9 people were wearing a mask (neither of the employees).   Governor Evers mask mandate for Wisconsin has fell on deaf ears.     That's what happens when you push against everything gathering of people except the DNC and BLM protests.   🤷‍♂️

 
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